Martínez-Frías M L, Rodríguez-Pinilla E, Bermejo E, Prieto L
ECEMC and Departamento de Farmacología, Facultad de Medicina, Universidad Complutense, Madrid, Spain.
Am J Med Genet. 2002 Nov 1;112(4):335-7. doi: 10.1002/ajmg.10706.
In 1997, Narchi and Kulaylat, studying the incidence of Down syndrome in infants of gestational diabetic mothers, concluded that maternal diabetes increases the risk for Down syndrome, but failed to control the maternal age in their analysis. Using data from the Spanish Collaborative Study of Congenital Malformations (ECEMC), we analyzed the relationship between Down syndrome and maternal diabetes mellitus, and maternal gestational diabetes, controlling the maternal age through the pair-matching analysis, stratifying by maternal age and logistic regression analysis. The analyses show that maternal age is related either to Down syndrome as well as to both types of maternal diabetes. Thus, the overall analysis could be confounded by maternal age. Once we controlled the maternal age, the risk of maternal diabetes mellitus for Down syndrome is: odds ratio (OR) = 0.92 (0.41-2.07); P = 0.83. Controlling maternal age in gestational diabetes, the risk is OR = 1.18 (0.61-2.35); P > 0.70. Based on our results, we conclude that Down syndrome is related to maternal age, but does not seem to be related to any type of maternal diabetes.
1997年，纳奇和库莱拉特在研究妊娠糖尿病母亲所生婴儿的唐氏综合征发病率时得出结论，认为母亲患糖尿病会增加唐氏综合征的风险，但他们在分析中未对母亲年龄进行控制。利用西班牙先天性畸形协作研究（ECEMC）的数据，我们分析了唐氏综合征与母亲糖尿病及母亲妊娠糖尿病之间的关系，并通过配对分析、按母亲年龄分层以及逻辑回归分析对母亲年龄进行了控制。分析表明，母亲年龄与唐氏综合征以及两种类型的母亲糖尿病均有关联。因此，总体分析可能会受到母亲年龄的混淆。在我们对母亲年龄进行控制后，母亲患糖尿病导致唐氏综合征的风险为：比值比（OR）=0.92（0.41 - 2.07）；P = 0.83。在妊娠糖尿病中控制母亲年龄后，风险为OR = 1.18（0.61 - 2.35）；P > 0.70。基于我们的研究结果，我们得出结论，唐氏综合征与母亲年龄有关，但似乎与任何类型的母亲糖尿病均无关联。
