Ribeiro Karina de Cássia Braga, Kowalski Luiz Paulo, Saba Leda Maria Buazar, de Camargo Beatriz
Hospital Cancer Registry Coordinator, Centro de Tratamento e Pesquisa Hospital do Câncer A. C. Camargo, R. Prof. Antonio Prudente, 211 São Paulo-SP, CEP 01509-900 Brazil.
Med Pediatr Oncol. 2002 Dec;39(6):594-600. doi: 10.1002/mpo.10168.
Epithelial neoplasms of salivary gland origin are relatively uncommon in children and adolescents. Over a 44-year period, there were 38 cases affecting children under 19 years of age in our Pediatric Hospital-Based Tumor Registry.
Medical charts of 38 patients with epithelial neoplasms of salivary glands were reviewed. Data collected included demographic, clinical, and histological characteristics. Statistical analysis included descriptive statistics, Student t-test, and Kaplan-Meier method was used for survival analysis.
The mean age was 11.8 years. There was a female preponderance of 1.9:1. The parotid gland was affected in most cases (65.8%). Twenty-seven patients had malignant tumors and eleven patients presented benign neoplasms. Pleomorphic adenoma was the most frequent benign tumor (7 out of 11) and mucoepidermoid carcinoma was the most frequent malignancy (17 out of 27). Five-year overall survival rate was 81.6% for patients with malignant tumors. Grade of differentiation was the only significant prognostic factor for patients with mucoepidermoid carcinomas.
Epithelial salivary gland tumors are very rare in children. Surgery is the best option to achieve high cure rates and radiotherapy must have precise indications because of their long-term side effects in young age.
涎腺来源的上皮性肿瘤在儿童和青少年中相对少见。在44年期间，我们基于儿童医院的肿瘤登记处有38例19岁以下儿童受该疾病影响。
回顾了38例涎腺上皮性肿瘤患者的病历。收集的数据包括人口统计学、临床和组织学特征。统计分析包括描述性统计，采用学生t检验，生存分析采用Kaplan-Meier法。
平均年龄为11.8岁。女性占优势，比例为1.9:1。大多数病例（65.8%）累及腮腺。27例患者患有恶性肿瘤，11例患者为良性肿瘤。多形性腺瘤是最常见的良性肿瘤（11例中的7例），黏液表皮样癌是最常见的恶性肿瘤（27例中的17例）。恶性肿瘤患者的5年总生存率为81.6%。分化程度是黏液表皮样癌患者唯一重要的预后因素。
涎腺上皮性肿瘤在儿童中非常罕见。手术是实现高治愈率的最佳选择，由于放疗对年轻患者有长期副作用，必须有精确的指征。
