钌双水杨醛缩乙二胺配合物在水溶液和有机溶液中的一氧化氮光释放
Nitric oxide photorelease from ruthenium salen complexes in aqueous and organic solutions.
作者信息
Bordini Jeane, Hughes David L, Da Motta Neto Joaquim Delphino, da Cunha Carlos Jorge
机构信息
Departamento de Química, Centro Politécnico, Universidade Federal do Paraná, Caixa Postal 19081, CEP 81531990, Curitiba-PR, Brazil.
出版信息
Inorg Chem. 2002 Oct 21;41(21):5410-6. doi: 10.1021/ic011273d.
The complexes [Ru(salen)(NO)Cl] and Ru(salen)(NO)(H(2)O) were shown to release the nitrosyl ligand as nitric oxide upon exposure to visible light in organic and aqueous solutions respectively, by means of UV-visible, EPR, and FTIR spectroscopies. The former was prepared by a new synthetic route and had its structure determined by single-crystal X-ray diffraction. A crystal of the dichloromethane solvate is orthorhombic, space group Fdd2 (No. 43) and formula C(16)H(14)ClN(3)O(3)Ru.CH(2)Cl(2), with Z = 16 and cell parameters a = 25.489(4), b = 33.435(4), and c = 9.3716(9) A. The electronic absorption spectra of the complexes were calculated using the INDO/S method. The water-soluble complex is a potential drug for antitumoral phototreatment.
通过紫外可见光谱、电子顺磁共振光谱和傅里叶变换红外光谱表明，配合物[Ru(salen)(NO)Cl]和[Ru(salen)(NO)(H₂O)]⁺分别在有机溶液和水溶液中暴露于可见光时会释放出作为一氧化氮的亚硝酰配体。前者通过新的合成路线制备，并通过单晶X射线衍射确定其结构。二氯甲烷溶剂化物的晶体为正交晶系，空间群Fdd2（编号43），化学式为C₁₆H₁₄ClN₃O₃Ru·CH₂Cl₂，Z = 16，晶胞参数a = 25.489(4)，b = 33.435(4)，c = 9.3716(9) Å。使用INDO/S方法计算了配合物的电子吸收光谱。水溶性配合物是一种用于抗肿瘤光疗的潜在药物。
Zotero 插件