Szincsák Nora, Hegyesi Hargita, Hunyadi Janos, Falus Andras, Juhász Istvan
Department of Dermatology, Debrecen University, Debrecen, Hungary.
Cell Biol Int. 2002;26(9):833-6. doi: 10.1016/s1065-6995(02)90934-0.
Melanoma cells and tissues contain considerable amounts of histamine and express histamine receptors, suggesting the existence of autocrine and paracrine regulation by histamine. Our previous in vitro results suggested that histamine elevates melanoma cell growth through the H2 receptor. In this work we show that in vivo tumour proliferation in immunodeficient mice xenotransplanted with a human melanoma cell line is diminished by cimetidine, an H2 receptor antagonist, if combined with a tamoxifen derivate acting on cytochrome p450 molecules (DPPE). Ranitidine, another H2 receptor antagonist, has a weaker inhibitory effect, the kinetics and mechanism of which is probably dissimilar to that of the cimetidine/DPPE mixture.
黑色素瘤细胞和组织含有大量组胺并表达组胺受体，这表明存在组胺的自分泌和旁分泌调节。我们之前的体外实验结果表明，组胺通过H2受体促进黑色素瘤细胞生长。在本研究中，我们发现，在用人黑色素瘤细胞系异种移植的免疫缺陷小鼠体内，H2受体拮抗剂西咪替丁若与作用于细胞色素p450分子的他莫昔芬衍生物（DPPE）联合使用，可减少肿瘤增殖。另一种H2受体拮抗剂雷尼替丁的抑制作用较弱，其动力学和作用机制可能与西咪替丁/DPPE混合物不同。
