Lawson J A, Adams W J, Morris D L
UNSW Department of Surgery, The St. George Hospital, Kogarah Sydney, Australia.
Br J Cancer. 1996 Apr;73(7):872-6. doi: 10.1038/bjc.1996.155.
Histamine has recently been shown to be a growth factor for some gastric and colorectal cancer cells. Previous studies have shown that cimetidine blocks in vitro and in vivo histamine-stimulated growth and cAMP release from the human colonic cancer cell line, C170. In this study, ranitidine, another H2 receptor antagonist, did not affect either basal or histamine-stimulated in vitro proliferation of C170, and failed to prevent cAMP release in vitro. Ranitidine did not inhibit in vivo growth of C170 at a dose of 1, 10, 25, 50 or 100 mg/kg, in contrast to 50 mg/kg/day cimetidine, which produced 39.3% inhibition of tumour volume (p<0.01) after 23 days' treatment. Ranitidine did not inhibit in vivo histamine-stimulated growth of C170 cells . LIM2412, another colonic cancer cell line, was significantly stimulated by both cimetidine and ranitidine in vivo. Ranitidine had no effect on in vitro cell proliferation.
组胺最近被证明是某些胃癌和结肠癌细胞的生长因子。先前的研究表明，西咪替丁在体外和体内均可阻断组胺刺激的人结肠癌细胞系C170的生长以及cAMP释放。在本研究中，另一种H2受体拮抗剂雷尼替丁对C170的基础或组胺刺激的体外增殖均无影响，且未能阻止体外cAMP释放。与50mg/kg/天的西咪替丁相反，雷尼替丁在1、10、25、50或100mg/kg剂量下均未抑制C170的体内生长，西咪替丁在治疗23天后对肿瘤体积的抑制率为39.3%（p<0.01）。雷尼替丁未抑制体内组胺刺激的C170细胞生长。另一种结肠癌细胞系LIM2412在体内受到西咪替丁和雷尼替丁的显著刺激。雷尼替丁对体外细胞增殖无影响。
