Adams Sue, Brown Heidi, Turner Gareth
Malaria Research Group, Nuffield Dept of Clinical Laboratory Sciences, Oxford Wellcome Centre for Tropical and Infectious Diseases, John Radcliffe Hospital, Oxford, UK OX3 9DU.
Trends Parasitol. 2002 Aug;18(8):360-6. doi: 10.1016/s1471-4922(02)02353-x.
Cerebral malaria is a major killer in the developing world, but we still know very little about the causes of this disease. How does Plasmodium falciparum cause such a devastating neurological disease while it is in the brain vasculature? Why do some patients die, whereas others survive? What processes contribute to disease in the brain, and can we reverse them? Here, the latest evidence from post-mortem, in vitro and animal studies is reviewed to highlight the role of blood-brain barrier breakdown in cerebral malaria. Blood-brain barrier integrity is disturbed during severe malaria, causing leakage of cerebral vessels. Understanding how this happens and how it contributes to the pathogenesis of coma may provide new opportunities for the treatment of cerebral malaria.
脑型疟疾是发展中世界的主要杀手，但我们对这种疾病的病因仍知之甚少。恶性疟原虫在脑血管系统中时，是如何引发如此具有毁灭性的神经系统疾病的？为什么有些患者死亡，而另一些患者却存活下来？哪些过程导致了脑部疾病，我们能否扭转这些过程？在此，我们回顾了来自尸检、体外和动物研究的最新证据，以突出血脑屏障破坏在脑型疟疾中的作用。在严重疟疾期间，血脑屏障的完整性受到干扰，导致脑血管渗漏。了解这一过程的发生机制及其如何导致昏迷的发病机制，可能为脑型疟疾的治疗提供新的机会。
