Cracowski Jean-Luc, Durand Thierry, Bessard Germain
Laboratoire de Pharmacologie, Faculté de Médecine de Grenoble, France.
Trends Pharmacol Sci. 2002 Aug;23(8):360-6. doi: 10.1016/s0165-6147(02)02053-9.
Isoprostanes are a complex family of compounds produced from arachidonic acid via a free-radical-catalyzed mechanism. They can be quantified as reliable markers of lipid peroxidation. Among the isoprostanes, 15-F(2t)-IsoP and 15-E(2t)-IsoP are biologically active and mediate vasoconstriction and bronchoconstriction and augment nociception. These effects are thought to be mediated via the activation of prostanoid TP receptors, with isoprostanes acting as full or partial agonists. A strong link between lipid peroxidation and diseases associated with ischaemia-reperfusion, atherosclerosis and inflammation has been suggested by elevated levels of F(2)-isoprostanes observed in such diseases. Thus, quantification of F(2)-isoprostanes as a pathophysiological marker provides a unique opportunity to investigate lipid peroxidation in human diseases and provides an interesting biomarker for rational dose selection of antioxidants in diseases where oxidative stress might be involved.
异前列腺素是通过自由基催化机制由花生四烯酸产生的一类复杂化合物。它们可作为脂质过氧化的可靠标志物进行定量。在异前列腺素中，15-F(2t)-异前列腺素和15-E(2t)-异前列腺素具有生物活性，可介导血管收缩和支气管收缩，并增强痛觉。这些作用被认为是通过类前列腺素TP受体的激活介导的，异前列腺素作为完全或部分激动剂发挥作用。在缺血再灌注、动脉粥样硬化和炎症相关疾病中观察到F(2)-异前列腺素水平升高，这表明脂质过氧化与这些疾病之间存在密切联系。因此，将F(2)-异前列腺素定量作为一种病理生理标志物，为研究人类疾病中的脂质过氧化提供了独特的机会，并为可能涉及氧化应激的疾病中合理选择抗氧化剂剂量提供了一个有趣的生物标志物。
