Poimenidou Anastasia A, Geraki Panagiota, Davidopoulou Sotiria, Kalfas Sotirios, Arhakis Aristidis
Department of Paediatric Dentistry, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece.
Department of Operative Dentistry, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece.
Antioxidants (Basel). 2025 Mar 28;14(4):405. doi: 10.3390/antiox14040405.
Numerous studies investigating oxidative stress in saliva in relation to dental caries and dental treatment focus on parameters such as total antioxidant capacity and malondialdehyde. This study is the first to utilize 8-isoprostane as a salivary biomarker to assess oxidative stress in relation to both caries and dental treatment. Salivary properties are also evaluated. The innovation of this study lies in its unique approach: although these salivary parameters have been examined individually in past research, this is the first study to evaluate them in conjunction with oxidative stress. A total of 26 children with caries and 20 caries-free children aged between 4 and 12 years old were included in this study. From both groups, stimulated saliva was collected and used to assess salivary properties and the 8-isoprostane level. For the caries group, the same measurements were also conducted after dental treatment. Children with caries had significantly lower levels of pH, and conductivity compared to caries-free children. The concentration of 8-isoprostane did not differ significantly between the two groups. In the caries group, dental treatment led to an increase in salivary conductivity and buffer capacity, along with a decrease in 8-isoprostane levels.
许多关于唾液氧化应激与龋齿及牙科治疗关系的研究都聚焦于总抗氧化能力和丙二醛等参数。本研究首次将8-异前列腺素用作唾液生物标志物，以评估与龋齿及牙科治疗相关的氧化应激。同时还对唾液特性进行了评估。本研究的创新之处在于其独特的方法：尽管这些唾液参数在以往研究中已被单独检测，但这是首次将它们与氧化应激结合起来进行评估。本研究共纳入了26名患有龋齿的儿童和20名4至12岁无龋齿的儿童。从两组中收集刺激唾液，用于评估唾液特性和8-异前列腺素水平。对于龋齿组，在牙科治疗后也进行了同样的测量。与无龋齿儿童相比，患有龋齿的儿童唾液pH值和电导率显著更低。两组之间8-异前列腺素的浓度没有显著差异。在龋齿组中，牙科治疗导致唾液电导率和缓冲能力增加，同时8-异前列腺素水平降低。
