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急性冠状动脉综合征:肌钙蛋白时代的生化策略

Acute coronary syndrome: biochemical strategies in the troponin era.

作者信息

Panteghini Mauro

机构信息

Laboratorio Analisi Chimico Cliniche 1, Azienda Ospedaliera Spedali Civili, 25125 Brescia, Italy.

出版信息

Chest. 2002 Oct;122(4):1428-35. doi: 10.1378/chest.122.4.1428.

Abstract

New biomarkers, such as cardiac troponins, have a major role to play for cost-effective management of individuals with acute chest pain and suspected coronary syndrome, and the laboratory is now poised to assume a vital role in assessing damage and determining prognosis. The redefined biochemical criterion proposed to classify acute coronary syndrome patients presenting with ischemic symptoms as patients with myocardial infarction is heavily predicated on an increased troponin concentration in blood. In an era of evidence-based medicine, we can no longer overlook the diagnostic and prognostic benefits provided by the measurement of these highly sensitive and specific proteins.

摘要

新的生物标志物,如心肌肌钙蛋白,在急性胸痛和疑似冠状动脉综合征患者的经济有效管理中发挥着重要作用,并且实验室现在已准备好在评估损伤和确定预后方面发挥至关重要的作用。提议将出现缺血症状的急性冠状动脉综合征患者分类为心肌梗死患者的重新定义的生化标准在很大程度上基于血液中肌钙蛋白浓度的升高。在循证医学时代,我们再也不能忽视测量这些高度敏感和特异的蛋白质所带来的诊断和预后益处。

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