Recavarren Ascencios Rosemary, Recavarren Arce Sixto
Servicio de Patologia de la Clinica Ricardo Palma y Departamento de Patologia del Hospital Nacional Cayetano Heredia.
Rev Gastroenterol Peru. 2002 Jul-Sep;22(3):199-205.
Chronic Atrophic Gastritis of high incidence in Helicobacter pylori infection has not been pathogenically explained yet. Helicobacter Pylori Chronic Active Superficial Gastritis has not been related to Chronic Atrophic Gastritis by some authors, who considered, until some time ago, that they both were independent lesions. In this study, we examined 42 antral or corporal gastric biopsies with Chronic Atrophic Gastritis at different stages, with histological lesions going from "deep lymphoid infiltration" in the proper gastric glands, to the replacement by fibro inflammatory tissue. With immunohystochemistry methods we have been able to prove that the lymphoid cells infiltrating the glandular part of the gastric mucous membrane are composed by CD8+(cytotoxic)T lymphocytes and by B lymphocites antibody secretors. In this study we suggest that cytotoxic T lymphocytes damage and destroy antral and corporal gastric proper glands, with further fibro inflammatory tissue replacement. Similar actions would be produced by B lymphocytes, but by secreting local antibodies against the cells from proper gastric glands.
幽门螺杆菌感染高发的慢性萎缩性胃炎的发病机制尚未得到解释。一些作者认为幽门螺杆菌慢性活动性浅表性胃炎与慢性萎缩性胃炎无关，直到不久前他们还认为二者是独立的病变。在本研究中，我们检查了42例处于不同阶段的慢性萎缩性胃炎的胃窦或胃体活检组织，其组织学病变从胃固有腺体的“深部淋巴浸润”到被纤维炎性组织替代。通过免疫组织化学方法，我们能够证明浸润胃黏膜腺体部分的淋巴细胞由CD8 +（细胞毒性）T淋巴细胞和分泌抗体的B淋巴细胞组成。在本研究中，我们认为细胞毒性T淋巴细胞损伤并破坏胃窦和胃体的固有腺体，进而被纤维炎性组织替代。B淋巴细胞也会产生类似作用，但通过分泌针对胃固有腺体细胞的局部抗体来实现。
