Niu Zhao-Shan, Li Bo-Kian, Wang Mei
Department of Pathology, Medical College of Qingdao University, Qingdao 266021, Shandong Province, China.
World J Gastroenterol. 2002 Oct;8(5):822-6. doi: 10.3748/wjg.v8.i5.822.
To investigate the possible roles of p53 and C-myc genes in the primary hepatocellular carcinogenesis and the relationship between the liver hyperplastic nodule (LHN) and hepatocellular carcinoma(HCC).
The expression of p53 and C-myc genes was detected immunohistochemically in 73 and 60 cases of HCC and pericarcinomatous tissues, respectively.
The positive expression of p53 in HCC was significantly higher than that in pericarcinomatous tissues (P<0.05). In pericarcinomatous tissues, the p53 expression was observed only in LHN, but not in liver cirrhosis (LC) and normal liver tissues. The positive expression rate of C-myc in HCC or LHN was significantly higher than that in LC or normal liver tissues (P<0.05 and P<0.01), however, no significant difference was found between HCC and LHN (P>0.05). The positive expression rate of p53 and C-myc in HCC was correlated with the histological differentiation, that in the poorly differentiated was significantly higher than that in well differentiated samples (P<0.05).
The overexpression of p53 and C-myc genes might play a role in the carcinogenesis of HCC; And LHN seems a preneoplastic lesion related to hepatocarcinogenesis; No evidence supports that LC contribute directly to the hepatocarcinogenesis.
探讨p53和C-myc基因在原发性肝细胞癌发生中的可能作用以及肝增生结节（LHN）与肝细胞癌（HCC）之间的关系。
分别采用免疫组织化学方法检测73例HCC及癌旁组织和60例HCC及癌旁组织中p53和C-myc基因的表达。
HCC中p53的阳性表达显著高于癌旁组织（P<0.05）。在癌旁组织中，仅在LHN中观察到p53表达，而在肝硬化（LC）和正常肝组织中未观察到。HCC或LHN中C-myc的阳性表达率显著高于LC或正常肝组织（P<0.05和P<0.01），然而，HCC与LHN之间未发现显著差异（P>0.05）。HCC中p53和C-myc的阳性表达率与组织学分化相关，低分化样本中的阳性表达率显著高于高分化样本（P<0.05）。
p53和C-myc基因的过表达可能在HCC的发生中起作用；并且LHN似乎是与肝癌发生相关的癌前病变；没有证据支持LC直接促成肝癌发生。
