丙泊酚可减轻冠状动脉搭桥手术期间的心肌脂质过氧化反应。

Propofol attenuates myocardial lipid peroxidation during coronary artery bypass grafting surgery.

作者信息

Sayin M M, Ozatamer O, Taşöz R, Kilinç K, Unal N

机构信息

Department of Anaesthesiology and Intensive Care, Ankara University Faculty of Medicine, Ankara, Turkey.

出版信息

Br J Anaesth. 2002 Aug;89(2):242-6. doi: 10.1093/bja/aef173.

DOI:10.1093/bja/aef173

PMID:12378660

Abstract

BACKGROUND

Propofol can scavenge free radicals because it has a chemical structure similar to antioxidants.

METHODS

We examined if free radical scavenging occurs with propofol during CABG operations. We studied 24 patients undergoing CABG surgery for triple vessel disease, randomized into two groups. After induction of anaesthesia with fentanyl 10 micrograms kg-1 and midazolam 0.1 mg kg-1, patients in the fentanyl group (n = 14) received fentanyl infusion 10-30 micrograms kg-1 h-1 and patients in the propofol group (n = 10) received propofol infusion 3-6 mg kg-1 h-1 for maintenance of anaesthesia. Atrial tissue biopsies were taken during cannulation for bypass, 45 min after cross-clamp insertion, 5 min after unclamping, and in the decannulation period. Lipid peroxidation was assessed by measurement of thiobarbituric acid reactive substances (TBARS) in the atrial tissue samples.

RESULTS

Lipid peroxidation in the propofol group was less than in the fentanyl group (P < 0.05) in all sampling periods. Lipid peroxidation in the fentanyl group increased significantly during cardiopulmonary bypass (CPB) (P < 0.05), but no increase was found in the propofol group (P > 0.05).

CONCLUSION

In clinical doses, propofol strongly attenuates lipid peroxidation during CABG surgery.

摘要

背景

丙泊酚具有与抗氧化剂相似的化学结构，因此能够清除自由基。

方法

我们研究了在冠状动脉旁路移植术（CABG）手术过程中丙泊酚是否具有清除自由基的作用。我们选取了24例因三支血管病变接受CABG手术的患者，随机分为两组。在给予10微克/千克芬太尼和0.1毫克/千克咪达唑仑诱导麻醉后，芬太尼组（n = 14）患者以10 - 30微克/千克·小时-1的速度输注芬太尼，丙泊酚组（n = 10）患者以3 - 6毫克/千克·小时-1的速度输注丙泊酚以维持麻醉。在体外循环插管期间、主动脉阻断钳夹插入后45分钟、松开阻断钳夹后5分钟以及拔管期间采集心房组织活检样本。通过测量心房组织样本中的硫代巴比妥酸反应物质（TBARS）来评估脂质过氧化情况。