头发中茚地那韦水平与高效抗逆转录病毒治疗的病毒学反应之间的关系。
Relationship between levels of indinavir in hair and virologic response to highly active antiretroviral therapy.
作者信息
Bernard Louis, Vuagnat Albert, Peytavin Gilles, Hallouin Marie-Charlotte, Bouhour Damien, Nguyen Thu Huyen, Vildé Jean Louis, Bricaire François, Raguin Gilles, de Truchis Pierre, Ghez David, Duong Michel, Perronne Christian
机构信息
Division of Infectious Diseases, Geneva University Hospital and Laboratoire de Virologie, Rue Micheli-du-Crest, CH 1211 Geneva, Switzerland.
出版信息
Ann Intern Med. 2002 Oct 15;137(8):656-9. doi: 10.7326/0003-4819-137-8-200210150-00009.
BACKGROUND
Suboptimal levels of antiretroviral drugs result in virologic failure in HIV-infected patients treated with highly active antiretroviral therapy (HAART).
OBJECTIVE
To assess the relationship between levels of indinavir in hair and virologic outcome.
DESIGN
Cross-sectional study.
SETTING
7 AIDS clinics in France.
PATIENTS
89 HIV-infected patients who received HAART that included indinavir.
MEASUREMENTS
Patients were classified as responders or nonresponders on the basis of viremia at the time of hair collection. In nonresponders, levels of indinavir in hair and resistance mutations in the protease gene were assessed at baseline and at the time of indinavir measurement.
RESULTS
Mean indinavir levels (+/-SD) were significantly higher in the 65 responders than in the 24 nonresponders (24.4 +/- 16 microg/g vs. 12.9 +/- 8.6 microg/g) (P < 0.001). Nonresponders with intermediate levels of indinavir in hair had more mutations in the protease gene than did nonresponders with low levels of indinavir in hair.
CONCLUSION
Indinavir levels in hair are associated with virologic outcome in patients receiving HAART.
背景
在接受高效抗逆转录病毒治疗（HAART）的HIV感染患者中，抗逆转录病毒药物水平欠佳会导致病毒学治疗失败。
目的
评估头发中茚地那韦水平与病毒学治疗结果之间的关系。
设计
横断面研究。
地点
法国的7家艾滋病诊所。
患者
89例接受包含茚地那韦的HAART治疗的HIV感染患者。
测量指标
根据采集头发时的病毒血症情况，将患者分为治疗有反应者和无反应者。对于无反应者，在基线时以及测量茚地那韦时评估头发中茚地那韦的水平和蛋白酶基因中的耐药突变情况。
结果
65例治疗有反应者的茚地那韦平均水平（±标准差）显著高于24例无反应者（24.4±16μg/g对12.9±8.6μg/g）（P<0.001）。头发中茚地那韦水平处于中等的无反应者，其蛋白酶基因中的突变比头发中茚地那韦水平低的无反应者更多。
结论
接受HAART治疗的患者，头发中的茚地那韦水平与病毒学治疗结果相关。
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