Gumà M, Olivé A, Roca J, Forcada J, Duró J C, Holgado S, Casado E, Mezquiriz X, Tena X
Rheumatology Section, Hospital Universitari Germans Trias I Pujol, Badalona, Spain.
Ann Rheum Dis. 2002 Nov;61(11):1024-6. doi: 10.1136/ard.61.11.1024.
To investigate joint laxity in patients with systemic lupus erythematosus (SLE).
University Hospital.
81 patients with SLE (1999 American College of Rheumatology criteria; 72 (89%) women and nine (11%) men, mean age 42.9 (SD 16.1) years), who regularly attended a specialist SLE clinic were examined. The control group comprised 280 patients attending a general practitioner (193 (69%) women and 87 (31%) men, mean age 44.7 (SD 11.2) years). Joint laxity was measured according to the criteria of Beighton et al (total score 4 or more). A regression analysis was performed.
Thirty nine (48%) patients with SLE and 42 (15%) of the control group were hypermobile. A logistic regression model was developed. The odds ratio of the association between laxity and SLE after adjustment for age and sex was 2.31 in the group younger than 49 years, and 17.99 in the group aged 49 years or older. Neither the clinical and analytical profile nor the use of corticosteroids was related to joint laxity.
Patients with SLE showed more hypermobility than controls. Hypermobility was more profound in older patients with SLE (> or =49 years). Joint laxity was not associated with any clinical or analytical pattern. Treatment with corticosteroids was not related to joint laxity.
研究系统性红斑狼疮（SLE）患者的关节松弛情况。
大学医院。
对81例定期前往SLE专科门诊就诊的SLE患者（符合1999年美国风湿病学会标准；72例（89%）为女性，9例（11%）为男性，平均年龄42.9（标准差16.1）岁）进行检查。对照组包括280例前往全科医生处就诊的患者（193例（69%）为女性，87例（31%）为男性，平均年龄44.7（标准差11.2）岁）。根据Beighton等人的标准测量关节松弛度（总分4分或更高）。进行了回归分析。
39例（48%）SLE患者和42例（15%）对照组患者关节活动过度。建立了逻辑回归模型。在调整年龄和性别后，49岁以下组关节松弛与SLE之间关联的比值比为2.31，49岁及以上组为17.99。临床和分析特征以及皮质类固醇的使用均与关节松弛无关。
SLE患者比对照组表现出更多的关节活动过度。年龄较大的SLE患者（≥49岁）关节活动过度更为明显。关节松弛与任何临床或分析模式均无关联。皮质类固醇治疗与关节松弛无关。
