多杀巴斯德菌毒素与波形蛋白的关联。
Association of Pasteurella multocida toxin with vimentin.
作者信息
Shime Hiroaki, Ohnishi Takahiro, Nagao Kaori, Oka Kiyomasa, Takao Toshifumi, Horiguchi Yasuhiko
机构信息
Department of Bacterial Toxinology, Research Institute for Microbial Diseases. Research Center for Structural and Functional Proteomics, Institute for Protein Research, Osaka University, Suita, Osaka 565-0871, Japan.
出版信息
Infect Immun. 2002 Nov;70(11):6460-3. doi: 10.1128/IAI.70.11.6460-6463.2002.
Abstract
To help understand the molecular mechanisms of Pasteurella multocida toxin (PMT) action, we searched for a cellular protein interacting with PMT. The ligand overlay assay revealed a 60-kDa cellular protein that binds to a region from the 840th to 985th amino acids of the toxin. This protein was identified as vimentin by peptide mass fingerprinting. The N-terminal head domain of vimentin was further found to be responsible for the binding to the toxin.
摘要
为了帮助理解多杀巴斯德菌毒素（PMT）作用的分子机制，我们寻找了一种与PMT相互作用的细胞蛋白。配体覆盖分析揭示了一种60 kDa的细胞蛋白，它与毒素第840至985个氨基酸区域结合。通过肽质量指纹图谱鉴定该蛋白为波形蛋白。进一步发现波形蛋白的N端头部结构域负责与毒素的结合。
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