多杀巴斯德菌毒素与波形蛋白的关联。
Association of Pasteurella multocida toxin with vimentin.
作者信息
Shime Hiroaki, Ohnishi Takahiro, Nagao Kaori, Oka Kiyomasa, Takao Toshifumi, Horiguchi Yasuhiko
机构信息
Department of Bacterial Toxinology, Research Institute for Microbial Diseases. Research Center for Structural and Functional Proteomics, Institute for Protein Research, Osaka University, Suita, Osaka 565-0871, Japan.
出版信息
Infect Immun. 2002 Nov;70(11):6460-3. doi: 10.1128/IAI.70.11.6460-6463.2002.
Abstract
To help understand the molecular mechanisms of Pasteurella multocida toxin (PMT) action, we searched for a cellular protein interacting with PMT. The ligand overlay assay revealed a 60-kDa cellular protein that binds to a region from the 840th to 985th amino acids of the toxin. This protein was identified as vimentin by peptide mass fingerprinting. The N-terminal head domain of vimentin was further found to be responsible for the binding to the toxin.
摘要
为了帮助理解多杀巴斯德菌毒素（PMT）作用的分子机制，我们寻找了一种与PMT相互作用的细胞蛋白。配体覆盖分析揭示了一种60 kDa的细胞蛋白，它与毒素第840至985个氨基酸区域结合。通过肽质量指纹图谱鉴定该蛋白为波形蛋白。进一步发现波形蛋白的N端头部结构域负责与毒素的结合。
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本文引用的文献
1
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Infect Immun. 2001 Dec;69(12):7839-50. doi: 10.1128/IAI.69.12.7839-7850.2001.
2
Escherichia coli cytotoxic necrotizing factors and Bordetella dermonecrotic toxin: the dermonecrosis-inducing toxins activating Rho small GTPases.
Toxicon. 2001 Nov;39(11):1619-27. doi: 10.1016/s0041-0101(01)00149-0.
3
Biological activity of a C-terminal fragment of Pasteurella multocida toxin.
Infect Immun. 2001 Jun;69(6):3628-34. doi: 10.1128/IAI.69.6.3628-3634.2001.
4
Pleiotropic effects of Pasteurella multocida toxin are mediated by Gq-dependent and -independent mechanisms. involvement of Gq but not G11.
J Biol Chem. 2001 Feb 9;276(6):3840-5. doi: 10.1074/jbc.M007819200. Epub 2000 Nov 2.
5
Activation of rho through a cross-link with polyamines catalyzed by Bordetella dermonecrotizing toxin.
EMBO J. 2000 Feb 15;19(4):521-30. doi: 10.1093/emboj/19.4.521.
6
Pasteurella multocida toxin stimulates mitogen-activated protein kinase via G(q/11)-dependent transactivation of the epidermal growth factor receptor.
J Biol Chem. 2000 Jan 21;275(3):2239-45. doi: 10.1074/jbc.275.3.2239.
7
Specific accumulation of Rho-associated kinase at the cleavage furrow during cytokinesis: cleavage furrow-specific phosphorylation of intermediate filaments.
Oncogene. 1999 Apr 29;18(17):2783-8. doi: 10.1038/sj.onc.1202633.
8
Roles of Rho-associated kinase in cytokinesis; mutations in Rho-associated kinase phosphorylation sites impair cytokinetic segregation of glial filaments.
J Cell Biol. 1998 Nov 30;143(5):1249-58. doi: 10.1083/jcb.143.5.1249.
9
Pasteurella multocida toxin increases endothelial permeability via Rho kinase and myosin light chain phosphatase.
J Immunol. 1998 Nov 15;161(10):5640-6.
10
Pasteurella multocida toxin and Bordetella bronchiseptica dermonecrotizing toxin elicit similar effects on cultured cells by different mechanisms.
J Vet Med Sci. 1998 Mar;60(3):301-5. doi: 10.1292/jvms.60.301.
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