Fontana Luis Oscar, García García Felipe, Arcas Martínez Salas Isabel, García Ligero Julián, Tomás Ros Mariano, Rico Galiano José Luis, Sempere Gutiérrez Andrés, Canteras Jordana Manuel
Servicio de Urología y Servicio de Anatomía Patológica, Hospital General Universitario de Murcia, España.
Arch Esp Urol. 2002 Sep;55(7):792-6.
To evaluate P 53 and c-erb-2 overexpression as a prognostic factor for progression and survival in patients with renal pelvis and ureter tumors.
Retrospective review of the medical records and pathology/immunohistochemical reports of 61 patients who underwent surgery for upper urinary tract urothelial tumors. Immunohistochemical studies were performed using the STREPTAVIDIN-BIOTIN-PEROXIDASE techniques with a LASAB kit (DAKO). Pearson's Chi square for 2 x 2 contingency tables and residues analysis were used for non continuous variables, with a confidence level of p < 0.05. COX multivariate analysis and survival curves were used for multiple variables association.
A higher P 53 overexpression was related with tumour dependent death (p < 0.001). These patients have their long term survival compromised. C-erb-2 overexpression is not statistically related to either proliferation or cancer specific death in upper urinary tract urothelial tumors.
In our series P53 overexpression has prognostic value in upper urinary tract urothelial tumors, but c-erb-2 did has not prognostic value.
评估P53和c-erb-2过表达作为肾盂和输尿管肿瘤患者病情进展及生存的预后因素。
回顾性分析61例接受上尿路尿路上皮肿瘤手术患者的病历及病理/免疫组化报告。采用链霉亲和素-生物素-过氧化物酶技术及LASAB试剂盒（达科公司）进行免疫组化研究。对于2×2列联表，使用Pearson卡方检验和残差分析处理非连续变量，置信水平为p<0.05。采用COX多变量分析和生存曲线分析多变量关联。
较高的P53过表达与肿瘤相关死亡有关（p<0.001）。这些患者的长期生存受到影响。c-erb-2过表达在上尿路尿路上皮肿瘤中与增殖或癌症特异性死亡均无统计学关联。
在我们的研究系列中，P53过表达在上尿路尿路上皮肿瘤中具有预后价值，但c-erb-2不具有预后价值。
