血清鳞状细胞癌抗原水平作为外阴癌患者腹股沟股淋巴结转移的预测指标。
Serum levels of squamous cell carcinoma antigen as a predictor of inguinofemoral lymph node metastasis in patients with vulvar cancer.
作者信息
Nather Andreas, Sami Ariane, Hefler Lukas, Leodolter Sepp, Joura Elmar A
机构信息
Department of Gynecology and Obstetrics, University of Vienna General Hospital, Währinger Gürtel 18-20, A-1090 Vienna, Austria.
出版信息
J Reprod Med. 2002 Sep;47(9):718-20.
OBJECTIVE
To evaluate the predictive value of preoperatively determined squamous cell carcinoma antigen (SCC-Ag) serum levels for the risk of inguinofemoral lymph node metastasis.
STUDY DESIGN
In this retrospective trial, preoperative serum levels of SCC-Ag in 29 patients with invasive squamous cell vulvar cancer (pT1 + 2) were evaluated and compared with nodal status.
RESULTS
Twenty patients had negative inguinofemoral nodes, whereas in nine an inguinofemoral lymph node metastasis could be observed. The median SCC-Ag in women with negative nodes was 1.3 micrograms/L (0.2-11.5) and with positive nodes, 2.7 micrograms/L (0.4-9.1) (P = .35).
CONCLUSION
Measurement of the serum level of SCC-Ag cannot be used for preoperative evaluation of the risk of lymph node metastasis in patients with clinically localized tumors since there is a significant overlap between both cohorts.
目的
评估术前测定的鳞状细胞癌抗原（SCC-Ag）血清水平对腹股沟股淋巴结转移风险的预测价值。
研究设计
在这项回顾性试验中，对29例浸润性外阴鳞状细胞癌（pT1 + 2）患者的术前血清SCC-Ag水平进行评估，并与淋巴结状态进行比较。
结果
20例患者腹股沟股淋巴结阴性，而9例可观察到腹股沟股淋巴结转移。淋巴结阴性女性的SCC-Ag中位数为1.3微克/升（0.2 - 11.5），淋巴结阳性女性为2.7微克/升（0.4 - 9.1）（P = 0.35）。
结论
由于两组之间存在显著重叠，因此不能将SCC-Ag血清水平的测量用于临床局限性肿瘤患者淋巴结转移风险的术前评估。
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