Takeshima N, Hirai Y, Katase K, Yano K, Yamauchi K, Hasumi K
Department of Gynecology, Cancer Institute Hospital, Tokyo, Japan.
Gynecol Oncol. 1998 Mar;68(3):263-6. doi: 10.1006/gyno.1998.4939.
Preoperative serum squamous cell carcinoma antigen (SCC) levels were examined in 148 cases of stage Ib squamous cervical cancer undergoing radical hysterectomy. The effect of the pelvic lymph node status on the marker level was examined by comparing 113 cases with cancer limited to the uterus and 23 cases with cancer confined to the uterus and pelvic lymph nodes using two different multivariate analyses. Ninety-five percent of patients with cancer limited to the uterus showed SCC levels of 4 ng/ml or below. Nearly two-thirds (65%) of patients with serum levels above 4 ng/ml exhibited pelvic lymph node metastasis. The marker values exceeding 4 ng/ml increased the risk of nodal metastasis by eight times, compared with serum levels of 4 ng/ml or below. Multivariate analyses confirmed that the pelvic lymph node metastasis had a larger impact on the marker level than did tumor size or depth of stromal infiltration. SCC levels greater than 4 ng/ml can be considered a high-risk zone for nodal metastasis.
对148例接受根治性子宫切除术的Ib期宫颈鳞癌患者术前血清鳞状细胞癌抗原（SCC）水平进行了检测。通过两种不同的多变量分析，比较了113例癌症局限于子宫的患者和23例癌症局限于子宫及盆腔淋巴结的患者，研究盆腔淋巴结状态对标志物水平的影响。95%癌症局限于子宫的患者SCC水平在4 ng/ml及以下。血清水平高于4 ng/ml的患者中，近三分之二（65%）出现盆腔淋巴结转移。与SCC水平在4 ng/ml及以下相比，标志物值超过4 ng/ml使淋巴结转移风险增加了8倍。多变量分析证实，盆腔淋巴结转移对标志物水平的影响大于肿瘤大小或间质浸润深度。SCC水平大于4 ng/ml可被视为淋巴结转移的高危区域。
