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阿扑吗啡诱导乌龟刻板咬行为与多巴胺能机制的关系。

Apomorphine-induced stereotyped biting in the tortoise in relation to dopaminergic mechanisms.

作者信息

Andersen H, Braestrup C, Randrup A

出版信息

Brain Behav Evol. 1975;11(5-6):365-73. doi: 10.1159/000123646.

DOI:10.1159/000123646
PMID:1238150
Abstract

A biting behavior in the Moroccan pond tortoise (Clemmys caspica leprósa) after apomorphine administration is described. The biting behavior was antagonized by the specific anti-dopaminergic drug haloperidol (10 mg/kg) and trifluperazine (15 mg/kg). The behavior was compared to similar behaviors in birds and mammals. The dopamine metabolites, homovanillic acid and 3,4-dihydroxyphenylacetic acid, were measured by a gas chromatographic method in the tortoise brain. From the effects on behavior and the changes in the level of these metabolites upon drug administration it was concluded that the dopamine system in the tortoise is qualitatively similar to that in birds and mammals but less sensitive to blockade.

摘要

本文描述了给予阿扑吗啡后摩洛哥池龟(Clemmys caspica leprósa)的咬咬行为。这种咬咬行为可被特异性抗多巴胺能药物氟哌啶醇(10毫克/千克)和三氟拉嗪(15毫克/千克)所拮抗。将该行为与鸟类和哺乳动物的类似行为进行了比较。采用气相色谱法测定了龟脑中多巴胺代谢产物高香草酸和3,4-二羟基苯乙酸的含量。根据药物给药后对行为的影响以及这些代谢产物水平的变化得出结论,龟的多巴胺系统在性质上与鸟类和哺乳动物的相似,但对阻断作用的敏感性较低。

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Apomorphine-induced stereotyped biting in the tortoise in relation to dopaminergic mechanisms.阿扑吗啡诱导乌龟刻板咬行为与多巴胺能机制的关系。
Brain Behav Evol. 1975;11(5-6):365-73. doi: 10.1159/000123646.
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