FTO 在神经精神疾病中的新兴作用。
Emerging Roles of FTO in Neuropsychiatric Disorders.
机构信息
Department of Histology and Embryology, Institute of Clinical Anatomy & Reproductive Medicine, School of Basic Medicine, Hengyang Medical School, University of South China, 421001 Hunan, China.
出版信息
Biomed Res Int. 2022 Apr 26;2022:2677312. doi: 10.1155/2022/2677312. eCollection 2022.
FTO (fat mass and obesity associated) is a recently discovered gene related to obesity and expressed in various tissues of the human body, especially with high expression in the brain. Earlier studies have found that FTO is involved in several biological processes, including brain development and function. In particular, recent studies have found that FTO is a demethylase of N6-methyladenosine (m6A) and it can affect neurological function through the m6A modification of mRNA. At present, a number of studies have shown that FTO is associated with many neuropsychiatric disorders. This paper reviews the discovery, structure, function, and tissue expression of FTO followed by discussing the relationship between FTO and neuropsychiatric diseases. In addition, the potential roles of FTO gene in drug addiction, major depression (MDD), and schizophrenia (SCZ) through regulating m6A modification of dopamine related genes were also highlighted.
FTO（肥胖与肥胖相关）是最近发现的与肥胖相关的基因，在人体的各种组织中表达，特别是在大脑中表达较高。早期研究发现，FTO 参与了几个生物学过程，包括大脑发育和功能。特别是，最近的研究发现 FTO 是 N6-甲基腺苷（m6A）的去甲基酶，它可以通过 mRNA 的 m6A 修饰来影响神经功能。目前，一些研究表明 FTO 与许多神经精神疾病有关。本文综述了 FTO 的发现、结构、功能和组织表达，接着讨论了 FTO 与神经精神疾病的关系。此外，还强调了 FTO 基因通过调节多巴胺相关基因的 m6A 修饰在药物成瘾、重度抑郁症（MDD）和精神分裂症（SCZ）中的潜在作用。
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