Erensoy S, Bilgiç A, Arda B, Ozer O
Dept. of Microbiology and Clinical Microbiology, Ege University Medical Faculty, Bornova, 35100 Izmir, Turkey.
Infection. 2002 Oct;30(5):303-5. doi: 10.1007/s15010-002-2078-1.
This is a report on the results of immunization of medical students with low-dose hepatitis B (HB) vaccine prior to starting clinical practice and evaluation of the efficacy of this vaccination scheme.
Low-dose (2 microg) recombinant HB vaccine was administered intramuscularly (im) at months 0, 1, 2 and 12 to 105 volunteers who wee HB surface antigen (HBsAg) and anti-HB core antigen (HBc) negative. Additional doses were administered after the third dose to the vaccines with anti-HBs titers below 10 IU/l.
Protective anti-HBs levels (above 10 IU/l) were obtained in 73.3%, 95.6%, 100% and 92.8% of vaccines with geometric mean titers of 91, 61.6, 3,662 and 367 IU/l at months 3, 12, 13 and 44 months, respectively.
Long-term effective protection against HB could be obtained in medical students with this scheme. Low-dose HB im vaccination can be utilized as a cost-saving vaccination strategy.
本文报告了医学生在开始临床实习前接种低剂量乙肝（HB）疫苗的结果以及该疫苗接种方案的效果评估。
对105名乙肝表面抗原（HBsAg）和抗乙肝核心抗原（HBc）均为阴性的志愿者，在第0、1、2和12个月分别肌肉注射（im）低剂量（2微克）重组HB疫苗。对第三剂后抗-HBs滴度低于10 IU/l的接种者给予额外剂量疫苗。
在第3、12、13和44个月时，分别有73.3%、95.6%、100%和92.8%的接种者获得了保护性抗-HBs水平（高于10 IU/l），几何平均滴度分别为91、61.6、3662和367 IU/l。
该方案可为医学生提供长期有效的乙肝防护。低剂量肌肉注射HB疫苗可作为一种节省成本的疫苗接种策略。
