Narimatsu Eichi, Kawamata Yurie, Kawamata Mikito, Fujimura Naoyuki, Namiki Akiyoshi
Department of Anesthesiology, Sapporo Medical University School of Medicine, South 1, West 16, Chuo-ku, Sapporo, Hokkaido 060-8543, Japan.
Brain Res. 2002 Oct 25;953(1-2):272-5. doi: 10.1016/s0006-8993(02)03375-9.
The effect of ketamine on CA1-field EPSPs (fEPSPs) in rat hippocampal slices was investigated. Ketamine (100 microM) facilitated fEPSPs at 0.05 Hz. The fEPSP facilitation was suppressed completely by AP-5 and partially by propranolol, and also by an increase in stimulation frequency. These results indicate that ketamine facilitates excitatory synaptic transmission by activating NMDA receptors via beta-adrenoceptors under conditions in which NMDA receptor channel block is slight.
研究了氯胺酮对大鼠海马脑片CA1区场兴奋性突触后电位（fEPSPs）的影响。氯胺酮（100微摩尔）在0.05赫兹时促进fEPSPs。AP-5可完全抑制fEPSP的促进作用，普萘洛尔和刺激频率增加可部分抑制。这些结果表明，在NMDA受体通道阻断轻微的条件下，氯胺酮通过β-肾上腺素能受体激活NMDA受体来促进兴奋性突触传递。
