线粒体DNA 5178A多态性与长寿
Mitochondrial DNA 5178A polymorphism and longevity.
作者信息
Yao Yong-Gang, Kong Qing-Peng, Zhang Ya-Ping
机构信息
Graduate School of The Chinese Academy of Sciences, Beijing, China.
出版信息
Hum Genet. 2002 Oct;111(4-5):462-3. doi: 10.1007/s00439-002-0826-z. Epub 2002 Aug 29.
Previous studies have shown that mitochondrial DNA (mtDNA) 5178 adenine/cytosine (5178A) polymorphism, which is one of the haplogroup-specific mutations for mtDNA haplogroup D, was apparently associated with aging and longevity in humans. We genotyped the 5178A in 293 samples representing three age groups (Old, n=95; Young, n=103; and Infant, n=95) from Yunnan Province, China. The distribution frequency of the 5178A in the Old samples (16.84%) is slightly higher than in those of the Young (13.59%) and Infant (15.79%), but the frequency difference between the age groups is far from being statistically significant ( P>0.05). Our results fail to support the suggestion of association between mtDNA 5178A (or haplogroup D) and longevity.
先前的研究表明，线粒体DNA（mtDNA）5178腺嘌呤/胞嘧啶（5178A）多态性是mtDNA单倍群D的单倍群特异性突变之一，显然与人类的衰老和长寿有关。我们对来自中国云南省的293个样本进行了5178A基因分型，这些样本代表了三个年龄组（老年组，n = 95；青年组，n = 103；婴儿组，n = 95）。5178A在老年样本中的分布频率（16.84%）略高于青年样本（13.59%）和婴儿样本（15.79%），但年龄组之间的频率差异远未达到统计学显著水平（P>0.05）。我们的结果未能支持mtDNA 5178A（或单倍群D）与长寿之间存在关联的观点。
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