2,3-二芳基-1,3-噻唑烷-4-（硫）酮衍生物的合成及其抗HIV活性
Synthesis and anti-HIV activity of 2,3-diaryl-1,3-thiazolidin-4-(thi)one derivatives.
作者信息
Rao Angela, Carbone Anna, Chimirri Alba, De Clercq Erik, Monforte Anna Maria, Monforte Pietro, Pannecouque Christophe, Zappalà Maria
机构信息
Dipartimento Farmaco-Chimico, Università di Messina, Italy.
出版信息
Farmaco. 2002 Sep;57(9):747-51. doi: 10.1016/s0014-827x(02)01268-5.
Abstract
Several 2,3-diaryl-1,3-thiazolidine-4-thione derivatives and 2,3-diaryl-1,3-thiazolidin-4-ones bearing a methyl group at C-5 position have been synthesized and tested as anti-HIV agents. The results of the in vitro tests showed that some of them proved to be effective inhibitors of HIV-1 replication.
摘要
已合成了几种2,3 - 二芳基 - 1,3 - 噻唑烷 - 4 - 硫酮衍生物以及在C - 5位带有甲基的2,3 - 二芳基 - 1,3 - 噻唑烷 - 4 - 酮，并作为抗HIV药物进行了测试。体外测试结果表明，其中一些化合物被证明是HIV - 1复制的有效抑制剂。
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