一些新型6-取代-3-(1-金刚烷基)-1,2,4-三唑并[3,4-b][1,3,4]噻二唑的合成及抗病毒活性评价
Synthesis and antiviral activity evaluation of some new 6-substituted 3-(1-adamantyl)-1,2,4-triazolo[3,4-b][1,3,4]thiadiazoles.
作者信息
Kritsanida Marina, Mouroutsou Anastasia, Marakos Panagiotis, Pouli Nicole, Papakonstantinou-Garoufalias Spyroula, Pannecouque Christophe, Witvrouw Myriam, De Clercq Erik
机构信息
Department of Pharmacy, University of Athens, Greece.
出版信息
Farmaco. 2002 Mar;57(3):253-7. doi: 10.1016/s0014-827x(01)01189-2.
Abstract
A number of novel 3,6-disubstituted 1,2,4-triazolo[3,4-b][1,3,4]thiadiazole derivatives, containing the adamantyl moiety, were synthesized and examined in various viral test systems. No antiviral effects were noted with any of the compounds at subtoxic concentrations in cell culture.
摘要
合成了一系列含有金刚烷基部分的新型3,6-二取代-1,2,4-三唑并[3,4-b][1,3,4]噻二唑衍生物，并在各种病毒测试系统中进行了检测。在细胞培养中，任何一种化合物在亚毒性浓度下均未观察到抗病毒作用。
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