• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

一些新型6-取代-3-(1-金刚烷基)-1,2,4-三唑并[3,4-b][1,3,4]噻二唑的合成及抗病毒活性评价

Synthesis and antiviral activity evaluation of some new 6-substituted 3-(1-adamantyl)-1,2,4-triazolo[3,4-b][1,3,4]thiadiazoles.

作者信息

Kritsanida Marina, Mouroutsou Anastasia, Marakos Panagiotis, Pouli Nicole, Papakonstantinou-Garoufalias Spyroula, Pannecouque Christophe, Witvrouw Myriam, De Clercq Erik

机构信息

Department of Pharmacy, University of Athens, Greece.

出版信息

Farmaco. 2002 Mar;57(3):253-7. doi: 10.1016/s0014-827x(01)01189-2.

DOI:10.1016/s0014-827x(01)01189-2
PMID:11989804
Abstract

A number of novel 3,6-disubstituted 1,2,4-triazolo[3,4-b][1,3,4]thiadiazole derivatives, containing the adamantyl moiety, were synthesized and examined in various viral test systems. No antiviral effects were noted with any of the compounds at subtoxic concentrations in cell culture.

摘要

合成了一系列含有金刚烷基部分的新型3,6-二取代-1,2,4-三唑并[3,4-b][1,3,4]噻二唑衍生物，并在各种病毒测试系统中进行了检测。在细胞培养中，任何一种化合物在亚毒性浓度下均未观察到抗病毒作用。

相似文献

1
Synthesis and antiviral activity evaluation of some new 6-substituted 3-(1-adamantyl)-1,2,4-triazolo[3,4-b][1,3,4]thiadiazoles.一些新型6-取代-3-(1-金刚烷基)-1,2,4-三唑并[3,4-b][1,3,4]噻二唑的合成及抗病毒活性评价
Farmaco. 2002 Mar;57(3):253-7. doi: 10.1016/s0014-827x(01)01189-2.
2
In-vitro anti-HIV and antitumor activity of new 3,6-disubstituted [1,2,4]triazolo[3,4-b][1,3,4]thiadiazoles and thiadiazine analogues.新型3,6-二取代[1,2,4]三唑并[3,4-b][1,3,4]噻二唑及噻二嗪类似物的体外抗HIV和抗肿瘤活性
Arch Pharm (Weinheim). 2008 Jun;341(6):365-9. doi: 10.1002/ardp.200700272.
3
3,6-Disubstituted 1,2,4-triazolo[3,4-b][1,3,4]thiadiazoles: synthesis and evaluation for antimicrobial and antiviral activity. III.3,6-二取代的1,2,4-三唑并[3,4-b][1,3,4]噻二唑：抗菌和抗病毒活性的合成与评价。III.
Farmaco. 1997 Apr;52(4):259-61.
4
Antiproliferative and antiviral activity of three libraries of adamantane derivatives.三个金刚烷衍生物文库的抗增殖和抗病毒活性。
Arch Pharm (Weinheim). 2014 May;347(5):334-40. doi: 10.1002/ardp.201300345. Epub 2014 Feb 13.
5
Synthesis and anticonvulsant activity of some novel fused heterocyclic 1,2,4-triazolo-[3,4-b]-1,3,4-thiadiazole derivatives.一些新型稠合杂环1,2,4-三唑并-[3,4-b]-1,3,4-噻二唑衍生物的合成与抗惊厥活性
Acta Pol Pharm. 2009 Mar-Apr;66(2):135-40.
6
Microwave-assisted synthesis and anti-HIV activity of new acyclic C-nucleosides of 3-(D-ribo-tetritol-1-yl)-5-mercapto-1,2,4-triazoles. Part 1.3-(D-核糖四醇-1-基)-5-巯基-1,2,4-三唑新型无环碳核苷的微波辅助合成及抗HIV活性。第1部分。
Nucleosides Nucleotides Nucleic Acids. 2008 May;27(5):469-83. doi: 10.1080/15257770802088829.
7
Synthesis of some 1,2,4-triazolo [3,4-b] [1,3,4]thiadiazoles as potential anthelmintics.一些作为潜在驱虫剂的1,2,4-三唑并[3,4-b][1,3,4]噻二唑的合成
Farmaco. 1989 Jul-Aug;44(7-8):703-9.
8
Design, enantiopure synthesis, and biological evaluation of novel iso-D-2',3'-dideoxy-3'-fluorothianucleoside derivatives as a bioisostere of lamivudine.新型异-D-2',3'-二脱氧-3'-氟硫代核苷衍生物作为拉米夫定生物电子等排体的设计、对映体纯合成及生物学评价
Nucleosides Nucleotides Nucleic Acids. 2007;26(8-9):911-5. doi: 10.1080/15257770701506426.
9
Studies on arylfuran derivatives-Part VI. Synthesis, characterization and antibacterial activities of some 6-(5-aryl-2-furyl)-1,2,4-triazolo [3,4-b]-1,3,4-thiadiazoles and 6-(5-nitro-2-furyl)-1,2,4-triazolo[3,4-b]-1,3,4-thiadiazoles.芳基呋喃衍生物的研究——第六部分。某些6-(5-芳基-2-呋喃基)-1,2,4-三唑并[3,4-b]-1,3,4-噻二唑和6-(5-硝基-2-呋喃基)-1,2,4-三唑并[3,4-b]-1,3,4-噻二唑的合成、表征及抗菌活性
Farmaco. 1996 Dec;51(12):785-92.
10
Synthesis, antimicrobial, and anti-inflammatory activities of novel 2-(1-adamantyl)-5-substituted-1,3,4-oxadiazoles and 2-(1-adamantylamino)-5-substituted-1,3,4-thiadiazoles.新型2-(1-金刚烷基)-5-取代-1,3,4-恶二唑和2-(1-金刚烷基氨基)-5-取代-1,3,4-噻二唑的合成、抗菌及抗炎活性
Eur J Med Chem. 2007 Feb;42(2):235-42. doi: 10.1016/j.ejmech.2006.10.003. Epub 2006 Nov 28.

引用本文的文献

1
Synthesis and Diuretic Activity of Substituted 1,3,4-Thiadiazoles.取代1,3,4-噻二唑的合成及其利尿活性
Scientifica (Cairo). 2022 Apr 8;2022:3011531. doi: 10.1155/2022/3011531. eCollection 2022.
2
Anticancer Activity of Triazolo-Thiadiazole Derivatives and Inhibition of AKT1 and AKT2 Activation.三唑并噻二唑衍生物的抗癌活性及对AKT1和AKT2激活的抑制作用。
Pharmaceutics. 2021 Apr 5;13(4):493. doi: 10.3390/pharmaceutics13040493.
3
Antibacterial, Mutagenic Properties and Chemical Characterisation of Sugar Bush ( Meisn.): A South African Native Shrub Species.
南非本土灌木物种糖布什（Meisn.）的抗菌、诱变特性及化学表征
Plants (Basel). 2020 Oct 9;9(10):1331. doi: 10.3390/plants9101331.
4
Agar-entrapped sulfonated DABCO: Agelly acidic catalyst for the acceleration of one-pot synthesis of 1,2,4-triazoloquinazolinone and some pyrimidine derivatives.琼脂包裹的磺化三乙烯二胺：用于加速一锅法合成1,2,4-三唑并喹唑啉酮及一些嘧啶衍生物的凝胶状酸性催化剂。
J Mol Struct. 2021 Feb 15;1226:129336. doi: 10.1016/j.molstruc.2020.129336. Epub 2020 Sep 26.
5
Facile, efficient and one-pot access to diverse new functionalized aminoalkyl and amidoalkyl naphthol scaffolds via green multicomponent reaction using triethylammonium hydrogen sulfate ([EtNH][HSO]) as an acidic ionic liquid under solvent-free conditions.通过使用三乙铵硫酸氢盐([EtNH][HSO₄])作为酸性离子液体，在无溶剂条件下，通过绿色多组分反应，简便、高效、一锅法获得多种新型功能化的氨烷基和酰胺基萘酚骨架。
Mol Divers. 2020 Feb;24(1):241-252. doi: 10.1007/s11030-019-09945-4. Epub 2019 Apr 5.
6
Antimicrobial metal-based thiophene derived compounds.基于金属的抗菌噻吩衍生化合物。
J Enzyme Inhib Med Chem. 2017 Dec;32(1):106-112. doi: 10.1080/14756366.2016.1238363. Epub 2016 Oct 21.
7
Cytotoxic and Antioxidant Activity of a Set of Hetero Bicylic Methylthiadiazole Hydrazones: A Structure-Activity Study.一组杂环双环甲基噻二唑腙的细胞毒性和抗氧化活性：构效关系研究
Int J Mol Cell Med. 2015 Spring;4(2):128-37.
8
Synthesis and RP HPLC studies of biologically active semicarbazides and their cyclic analogues 1,2,4-triazol-3-ones.生物活性氨基脲及其环状类似物1,2,4 - 三唑 - 3 - 酮的合成与反相高效液相色谱研究
Monatsh Chem. 2012;143(4):657-667. doi: 10.1007/s00706-011-0715-z. Epub 2012 Jan 28.
9
Crystal structure of 2-{[1-(4-bromo-benz-yl)-1H-1,2,3-triazol-4-yl]meth-oxy}naph-thalene-1,4-dione.2-{[1-(4-溴苄基)-1H-1,2,3-三唑-4-基]甲氧基}萘-1,4-二酮的晶体结构
Acta Crystallogr E Crystallogr Commun. 2015 Mar 11;71(Pt 4):o231-2. doi: 10.1107/S2056989015004429. eCollection 2015 Apr 1.
10
Pharmacological and structure-activity relationship evaluation of 4-aryl-1-diphenylacetyl(thio)semicarbazides.4-芳基-1-二苯基乙酰基（硫代）氨基脲的药理及构效关系评价
Molecules. 2014 Apr 16;19(4):4745-59. doi: 10.3390/molecules19044745.