Mitchell G, Heffron J J
J S Afr Vet Assoc. 1975 Jun;46(2):145-8.
Serum creatine phosphokinase activity was determined in German Landrace and Landrace x Large White pigs from 11 weeks to 28 weeks of age. A very pronounced age dependence of enzyme activity was observed in both groups, peak activities occurring at 19 weeks of age for the German Landrace and at 15 weeks for the crosses. The large increase in serum creatine phosphokinase activity observed occurred during the rapid phase of growth after which enzyme levels returned close to initial values. Sedatives and the stress of handling while obtaining blood can also cause raised serum creatine phosphokinase levels and complicate the interpretation of the data in regard to the detection of the stress syndrome. Enzyme activity also displayed a diurnal variation thus introducing a further parameter in the use of creatine phosphokinase activity for detection of the stress syndrome. Certain limitations in the method of measurement of creatine phosphokinase are discussed.
测定了11周龄至28周龄德国长白猪以及长白猪与大白猪杂交猪的血清肌酸磷酸激酶活性。在两组猪中均观察到酶活性与年龄有非常显著的相关性，德国长白猪的酶活性峰值出现在19周龄，杂交猪则出现在15周龄。观察到血清肌酸磷酸激酶活性的大幅增加发生在快速生长阶段，之后酶水平恢复到接近初始值。镇静剂以及采血时的处理应激也会导致血清肌酸磷酸激酶水平升高，从而使关于应激综合征检测的数据解读变得复杂。酶活性还呈现出昼夜变化，因此在使用肌酸磷酸激酶活性检测应激综合征时又引入了一个参数。文中讨论了肌酸磷酸激酶测量方法中的某些局限性。
