Beld A J, Van Den Hoven S, Wouterse A C, Zegers M A
Eur J Pharmacol. 1975 Feb;30(2):360-3. doi: 10.1016/0014-2999(75)90122-3.
The concentration-dependent binding of atropine-3 H to membrane fractions from bovine tracheal muscle, parotid gland and caudate nucleus, measured by equilibrium dialysis, revealed the presence of virtually identical high affinity binding sites in all three tissues. Sch 1000 and Sch 1178 geometrical isomers of N-isopropylatropine bromide with a large potency ratio as antimuscarinics, inhibited atropine binding identically in all three tissues. Differences in properties of muscarinic receptors in these tissues are either non-existent or too small to be detected by the applied techniques.
通过平衡透析法测定，阿托品 - 3H与牛气管肌肉、腮腺和尾状核膜组分的浓度依赖性结合表明，这三种组织中几乎存在相同的高亲和力结合位点。作为抗毒蕈碱剂具有很大效价比的N - 异丙基阿托品溴化物的Sch 1000和Sch 1178几何异构体，在所有三种组织中对阿托品结合的抑制作用相同。这些组织中毒蕈碱受体特性的差异要么不存在，要么太小而无法通过所应用的技术检测到。
