韦格纳肉芽肿病患者的Th1和Th2 CD4 + T细胞以及Tc1和Tc2 CD8 + T细胞。

Th1 and Th2 CD4+ T cells and Tc1 and Tc2 CD8+ T cells of patients with Wegener's granulomatosis.

作者信息

Ohta Nobuo, Fukase Shigeru, Fuse Takeo, Aoyagi Masaru

机构信息

Department of Otolaryngology, Yamagata University School of Medicine, Japan.

出版信息

J Laryngol Otol. 2002 Aug;116(8):605-9. doi: 10.1258/00222150260171597.

DOI:10.1258/00222150260171597

PMID:12389688

Abstract

A Th1/Th2 cytokine imbalance with a predominance of Th1 cytokines has been suggested to be of pathogenic importance in Wegener's granulomatosis. To evaluate the role of Th1/Th2 cytokines in Wegener's granulomatosis, the subsets of Th1, Th2, Tc1 and Tc2 cells from patients with active Wegener's granulomatosis were examined by intracellular cytokine flow cytometry. The population of Tc1 cells (72.0 +/- 14.4 per cent) in Wegener's granulomatosis was significantly increased compared with Tc1 cells (37.3 +/- 14.6 per cent) in control (p<0.05). Th1, Th2 and Tc2 cells in Wegener's granulomatosis were not significantly increased compared with the control cells. These results indicate that the predominance of Tc1 cells might contribute to the mechanism of the pathogenesis of Wegener's granulomatosis.

摘要

有人提出，以Th1细胞因子占优势的Th1/Th2细胞因子失衡在韦格纳肉芽肿病的发病机制中具有重要意义。为了评估Th1/Th2细胞因子在韦格纳肉芽肿病中的作用，采用细胞内细胞因子流式细胞术检测了活动期韦格纳肉芽肿病患者的Th1、Th2、Tc1和Tc2细胞亚群。与对照组的Tc1细胞（37.3±14.6%）相比，韦格纳肉芽肿病患者的Tc1细胞群体（72.0±14.4%）显著增加（p<0.05）。与对照细胞相比，韦格纳肉芽肿病患者的Th1、Th2和Tc2细胞没有显著增加。这些结果表明，Tc1细胞的优势可能有助于韦格纳肉芽肿病的发病机制。