Colasanti B K, Kosa J E, Craig C R
Psychopharmacologia. 1975 Oct 14;44(1):33-6. doi: 10.1007/BF00421180.
Rats rendered chronically epileptic by the implantation of cobalt in the right parietal cortex were simultaneously prepared with permanent cortical and temporalis muscle electrodes for longitudinal EEG and EMG recording. Animals treated similary with glass rods served as the controls. Wet dog shakes were quantified by counting the characteristic artifacts produced in the EEG tracings upon their appearance. The number of wet dog shakes exhibited by the control rats remained at a low and constant level over 18 days of recording. In contrast, wet dog shakes in the chronically epileptic rats began to increase by the fourth day after cobalt placement and remained significantly elevated up to the 18th day. Administration of reserpine to naive rats or to cobalt epileptic rats on days 7 and 9 after implantation resulted in an almost complete suppression of wet dog shakes which endured over a period of 3-5 days. These results suggest that the abnormally elevated wet dog shake response of the cobalt-epileptic rats and the spontaneous wet dog shake behavior of normal rats may be mediated by common neural pathways.
通过在右侧顶叶皮质植入钴使大鼠慢性癫痫发作，同时植入永久性皮质电极和颞肌电极，用于纵向脑电图（EEG）和肌电图（EMG）记录。用玻璃棒进行类似处理的动物作为对照。通过计算脑电图记录中出现湿狗样抖动时产生的特征性伪迹来量化湿狗样抖动。在18天的记录期内，对照大鼠表现出的湿狗样抖动次数保持在较低且恒定的水平。相比之下，慢性癫痫大鼠的湿狗样抖动在钴植入后第4天开始增加，并在第18天之前一直显著升高。在植入后第7天和第9天，给未处理的大鼠或钴诱导的癫痫大鼠注射利血平，几乎完全抑制了湿狗样抖动，这种抑制持续3 - 5天。这些结果表明，钴诱导的癫痫大鼠异常升高的湿狗样抖动反应和正常大鼠的自发性湿狗样抖动行为可能由共同的神经通路介导。
