[Heparin-induced extacorporeal low-density lipoprotein-lipoprotein alpha-fibrinogen precipitation in 36 cases].

OBJECTIVE

To observe the efficacy of heparin-induced extracorporeal low-density lipoprotein-lipoprotein alpha- fibrinogen precipitation (HELP) in clearing blood lipids.

METHODS

Thirty-six patients were subjected to extracorporeal plasma lipid separation procedures that utilized heparin to induce the formation of the complex consisted of heparin, low-density lipoprotein cholesterol (LDL-C), lipoprotein and fibrinogen which was precipitated and consequently separated from the plasma. Blood samples were obtained from the patients both before and after the procedures to assay serum total cholesterol (CH), triglyceride (TG), high-density lipoprotein cholesterol (HDL-C), LDL-C, apoliprotein A (ApoA) and apoliprotein B (ApoB).

RESULT

Significant differences were observed between the pre- and postoperative levels of lipoprotein (P<0.001).

CONCLUSION

Plasma lipoprotein can be partly cleared by way of HELP.