Naulaers G, Morren G, Van Huffel S, Casaer P, Devlieger H
Department of Paediatrics, University Hospital Leuven, Belgium.
Arch Dis Child Fetal Neonatal Ed. 2002 Nov;87(3):F189-92. doi: 10.1136/fn.87.3.f189.
To describe normal values of the cerebral tissue oxygenation index (TOI) in premature infants.
TOI was measured by spatially resolved spectroscopy in preterm infants on the first 3 days of life. Infants with an abnormal cranial ultrasound were excluded. Other simultaneously measured variables were PaO(2), PaCO(2), pH, mean arterial blood pressure, heart rate, haemoglobin, glycaemia, and peripheral oxygen saturation.
Fifteen patients with a median postmenstrual age of 28 weeks were measured. There was a significant increase in median TOI over the first 3 days of life: 57% on day 1, 66.1% on day 2, and 76.1% on day 3. Multiple regression analysis showed no correlation between TOI and postmenstrual age, peripheral oxygen saturation, mean arterial blood pressure, PaO(2), PaCO(2), and haemoglobin concentration.
Cerebral TOI increases significantly in the first 3 days of life in premature babies. This increase probably reflects the increase in cerebral blood flow at this time.
描述早产儿脑组织氧合指数（TOI）的正常值。
在出生后前3天，采用空间分辨光谱法测量早产儿的TOI。排除头颅超声异常的婴儿。同时测量的其他变量包括动脉血氧分压（PaO₂）、动脉血二氧化碳分压（PaCO₂）、pH值、平均动脉血压、心率、血红蛋白、血糖和外周血氧饱和度。
对15例孕龄中位数为28周的患儿进行了测量。出生后前3天，TOI中位数显著升高：第1天为57%，第2天为66.1%，第3天为76.1%。多元回归分析显示，TOI与孕龄、外周血氧饱和度、平均动脉血压、PaO₂、PaCO₂和血红蛋白浓度之间无相关性。
早产儿出生后前3天，脑TOI显著升高。这种升高可能反映了此时脑血流量的增加。
