Quaresima V, Sacco S, Totaro R, Ferrari M
Department of Biomedical Technologies, University of L'Aquila, Italy.
J Biomed Opt. 2000 Apr;5(2):201-5. doi: 10.1117/1.429987.
Spatially resolved spectroscopy (SRS) is a new near infrared spectroscopy (NIRS) method that, using the multi-distance approach, measures local cerebral cortex hemoglobin oxygen saturation [J. Matcher, P. Kirkpatrick, K. Nahid, M. Cope, and D. T. Delpy, Proc. SPIE 2389, 486-495 (1995)]. Using a conventional continuous wave NIRS photometer, cerebral venous oxygen saturation (SvO2) can be calculated from oxyhemoglobin and total hemoglobin rise induced by partial occlusion of jugular vein [C. E. Elwell, S. J. Matcher, L. Tyszczuk, J. H. Meek, and D. T. Delpy, Adv. Exp. Med. Biol. 411, 453-460 (1997)]. The aim of this study was to compare direct measurements of forehead tissue oxygenation index (TOI) with the calculated SvO2 during venous occlusion in 16 adult volunteers using a clinical two-channel SRS oximeter (NIRO-300). Measured TOI and calculated SvO2 values of either right or left forehead did not significantly differ. A good agreement between the two NIRS methods was also demonstrated. On 16 other subjects, no significant differences were found between the right and left forehead TOI values measured simultaneously, and between the TOI values measured by channel 1 or 2 on the same side. The results confirm that cerebral cortex hemoglobin oxygen saturation, measured directly by the SRS method, reflects predominantly the saturation of the intracranial venous compartment of circulation.
空间分辨光谱学（SRS）是一种新的近红外光谱学（NIRS）方法，它采用多距离方法测量局部大脑皮层血红蛋白氧饱和度[J. 马彻尔、P. 柯克帕特里克、K. 纳希德、M. 科普和D. T. 德尔皮，《国际光学工程学会汇刊》2389，486 - 495（1995年）]。使用传统的连续波NIRS光度计，可根据颈静脉部分阻塞引起的氧合血红蛋白和总血红蛋白升高来计算脑静脉氧饱和度（SvO2）[C. E. 埃尔韦尔、S. J. 马彻尔、L. 蒂什楚克、J. H. 米克和D. T. 德尔皮，《实验医学与生物学进展》411，453 - 460（1997年）]。本研究的目的是使用临床双通道SRS血氧计（NIRO - 300），比较16名成年志愿者在静脉阻塞期间前额组织氧合指数（TOI）的直接测量值与计算得到的SvO2。右前额或左前额的测量TOI值与计算得到的SvO2值无显著差异。两种NIRS方法之间也显示出良好的一致性。在另外16名受试者中，同时测量的右前额和左前额TOI值之间，以及同一侧通道1或通道2测量的TOI值之间均未发现显著差异。结果证实，通过SRS方法直接测量的大脑皮层血红蛋白氧饱和度主要反映循环中颅内静脉部分的饱和度。
