Levin R M, Seleny F L, Streczyn M V
Anesth Analg. 1975 Nov-Dec;54(6):800-5. doi: 10.1213/00000539-197511000-00031.
Ketamine, pancuronium, and alphaprodine were used as the primary anesthetic agents in 71 infants requiring cardiovascular operations during a recent 1-year period. This group of patients was compared with a similar group anesthetized 3 years before with d-tubocurarine, halothane, and/or N20-O2. Stability of the circulatory system was well maintained with ketamine-pancuronium-narcotic (KPN) during the induction period. However, once surgical dissection of the heart and great vessels began, hypotension/bradycardia, ventricular fibrillation, and 48-hour mortality were similar for the two groups. Therefore, using these criteria for analysis, the KPN technic, in spite of claims for its minimal adverse effect on the cardiovascular system, did not prove superior to the halothane-N2O-O2-curare technic.
在最近一年期间，氯胺酮、泮库溴铵和阿法罗定被用作71例需要进行心血管手术的婴儿的主要麻醉剂。将这组患者与3年前使用右旋筒箭毒碱、氟烷和/或N20 - O2麻醉的类似患者组进行比较。在诱导期，氯胺酮 - 泮库溴铵 - 麻醉剂（KPN）能很好地维持循环系统的稳定性。然而，一旦开始对心脏和大血管进行手术解剖，两组的低血压/心动过缓、心室颤动和48小时死亡率相似。因此，根据这些分析标准，尽管声称KPN技术对心血管系统的不良影响最小，但并未证明它优于氟烷 - N2O - O2 - 箭毒技术。
