Koszinowski U, Kruse F, Thomssen R
Arch Virol. 1975;48(4):335-45. doi: 10.1007/BF01317432.
The action of peritoneal exudate cells (PEC) from normal and vaccinia virus infected mice on infectious vaccinia virus particles was investigated in vitro. PEC from immune mice showed a significantly higher infectivity titre reduction (virus clearance, VC) than normal cells. This effect could be clearly attributed to the macrophage. Vaccinia virus multiplied in PEC from normal animals while there was no virus propagation in cells from immunized mice. The release of adsorbed or engulfed virus was reduced significantly in PEC from immunized animals. Anti-vaccinia-antibodies seem to activate normal macrophages to increased virus clearance. This stimulating effect was demonstrable only in the IgG fraction of the antiserum. The activity of macrophages from mice injected three times over a period of 14 days with vaccinia virus could be entirely blocked with anti-mouse-IgG, while PEC from mice injected one time six days previously were not inhibited.
对正常小鼠和感染痘苗病毒的小鼠的腹膜渗出细胞（PEC）在体外对感染性痘苗病毒颗粒的作用进行了研究。来自免疫小鼠的PEC显示出比正常细胞显著更高的感染性滴度降低（病毒清除，VC）。这种效应可明确归因于巨噬细胞。痘苗病毒在正常动物的PEC中增殖，而在免疫小鼠的细胞中没有病毒繁殖。免疫动物的PEC中吸附或吞噬的病毒释放显著减少。抗痘苗抗体似乎激活正常巨噬细胞以增加病毒清除。这种刺激作用仅在抗血清的IgG部分中可证实。在14天内分三次注射痘苗病毒的小鼠的巨噬细胞活性可被抗小鼠IgG完全阻断，而6天前单次注射的小鼠的PEC则未被抑制。
