衰老和长寿与生长激素/胰岛素样生长因子-1的分泌有关。

Ageing and longevity are related to growth hormone/insulin-like growth factor-1 secretion.

作者信息

Ruiz-Torres Antonio, Soares de Melo Kirzner Marcia

机构信息

University Research Institute of Gerontology and Metabolism, University Autónoma of Madrid, Madrid, Spain.

出版信息

Gerontology. 2002 Nov-Dec;48(6):401-7. doi: 10.1159/000065507.

DOI:10.1159/000065507

PMID:12393957

Abstract

BACKGROUND

It is known that the growth process is related to an individual's life-span, but the role of growth hormone (GH) secretion in human ageing remains unknown.

OBJECTIVE

This study has focussed on the influence of GH on ageing parameters and on its relationship with human longevity.

METHODS

To deal with the first issue, we compared ageing parameters of young (up to 39) and old (over 70) individuals having similar insulin-like growth factor-1 (IGF-1) blood levels. For the second one, the decline in IGF-1 levels was studied comparing its behaviour in the first half with that in the second half of adult life. The latter represents the period of life in which mortality progressively increases. Two hundred and five healthy individuals were chosen as subjects, well distributed by gender and age (between 19 and 93 years).

RESULTS

Old males with IGF-1 levels similar to young ones do not show the age-dependent decrease in serum testosterone and lean body mass, nor the increase in fat body mass. Other hormone-metabolic and nutritional parameters do not reveal any change compared with the results of all individuals. In females, the results do not allow to assume any IGF-1 influence. The behaviour of the linear regression in the second half of adult life of males, which becomes flat because old men having low IGF-1 blood levels die earlier, is consistent with these results. This effect, which is supported by predictive analysis, is not observed in females, i.e. the IGF-1 level declines in the second half of the women's adult life are only a little flatter than in the first half. Finally, extrapolating the regressions obtained in the first half of adulthood, the age at which the curve crosses the x-axis is 110 years for males and 132 for females.

CONCLUSIONS

The presented study of IGF-1 levels suggests that the GH secretion in adulthood plays a determinant role not only for some regressive manifestations, but also for life potential.

摘要

背景

已知生长过程与个体寿命相关，但生长激素（GH）分泌在人类衰老过程中的作用仍不清楚。

目的

本研究聚焦于GH对衰老参数的影响及其与人类长寿的关系。

方法

为解决第一个问题，我们比较了胰岛素样生长因子-1（IGF-1）血液水平相似的年轻（39岁及以下）和老年（70岁以上）个体的衰老参数。对于第二个问题，通过比较成年期前半段和后半段IGF-1水平的变化情况来研究其下降情况。成年期后半段是死亡率逐渐上升的时期。选取205名健康个体作为研究对象，按性别和年龄（19至93岁）进行了良好分布。

结果

IGF-1水平与年轻人相似的老年男性，血清睾酮和瘦体重并未出现随年龄增长而下降的情况，脂肪量也未增加。与所有个体的结果相比，其他激素代谢和营养参数未显示出任何变化。在女性中，结果无法表明IGF-1有任何影响。男性成年期后半段线性回归呈平缓状态，因为IGF-1血液水平低的老年男性更早死亡，这一结果与上述情况一致。预测分析支持了这一效应，而在女性中未观察到这种效应，即女性成年期后半段IGF-1水平的下降仅比前半段略平缓。最后，根据成年期前半段得到的回归进行外推，曲线与x轴相交时男性的年龄为110岁，女性为132岁。