Zouboulis Ch C
Klinik und Poliklinik für Dermatologie, Universitätsklinikum Benjamin Franklin, Freie Universität Berlin, Berlin.
Hautarzt. 2003 Sep;54(9):825-32. doi: 10.1007/s00105-003-0581-7.
Intrinsic skin aging is determined primarily by genetic factors and hormonal status. It reflects the same degenerative process seen in other organs. Skin function is one of the parameters most influenced by aging. The hormonal influences include reduced pituitary, adrenal and gonadal secretion. The hormonal changes of aging lead to the development of a specific body and skin phenotype. Individuals in developed lands spend up to a third of their life (women-post-menopausal) or perhaps 20 years (men-partial androgen deficiency of the aging man, PADAM) with oestrogen or androgen deficiency. Other hormones whose levels decrease with aging include melatonin, growth hormone (GH), dehydroepiandrosterone und insulin-like growth factor-I (IGF-I). Since the skin not only fulfils a protective function for the organism but is also an active peripheral endocrine organ, which even releases effective hormones in the circulation, local hormone substitution could become interesting in the future.
皮肤内在老化主要由遗传因素和激素状态决定。它反映了在其他器官中可见的相同退行性过程。皮肤功能是受衰老影响最大的参数之一。激素影响包括垂体、肾上腺和性腺分泌减少。衰老的激素变化导致特定身体和皮肤表型的出现。发达国家的人一生中高达三分之一的时间（绝经后女性）或可能20年（男性——老年男性部分雄激素缺乏，PADAM）处于雌激素或雄激素缺乏状态。其他随衰老而水平降低的激素包括褪黑素、生长激素（GH）、脱氢表雄酮和胰岛素样生长因子-I（IGF-I）。由于皮肤不仅对机体具有保护功能，而且还是一个活跃的外周内分泌器官，甚至能在循环中释放有效激素，局部激素替代在未来可能会变得很有意义。
