Vessman J, Strömberg S
J Pharm Sci. 1975 Feb;64(2):311-3. doi: 10.1002/jps.2600640226.
A method was developed for the quantitative GLC determination of nicotinamide. It is based on the conversion of nicotinamide to nicotinonitrile. This dehydration reaction is mediated with trifluoroacetic anhydride and catalyzed by base. The GLC properties of this nitrile are excellent. The reaction conditions, extraction, and stability properties of the derivative as well as the choice of internal standard are discussed.
开发了一种用于烟酰胺定量气相色谱测定的方法。它基于烟酰胺向烟腈的转化。这种脱水反应由三氟乙酸酐介导并由碱催化。该腈的气相色谱性质优异。讨论了衍生物的反应条件、萃取、稳定性以及内标物的选择。
