Rauchová Hana, Koudelová Jitka, Drahota Zdenĕk, Mourek Jindrich
Institute of Physiology, Academy of Sciences of the Czech Republic, Prague.
Neurochem Res. 2002 Sep;27(9):899-904. doi: 10.1023/a:1020339530924.
The exposure to hypobaric hypoxia increased lipid peroxidation as indicated by thiobarbituric acid-reactive substances [TBARS] in rat brain. Plasma lactate/pyruvate ratio was used as a marker of hypoxia. We compared the protective effect of alpha-tocopherol with the effect of L-carnitine or phosphocreatine. Rats pretreated with alpha-tocopherol, L-carnitine, or phosphocreatine had lower TBARS levels after the exposure to hypobaric hypoxia. However, lactate/ pyruvate ratio was improved only in rats pretreated with L-carnitine or phosphocreatine. We conclude from our data that, contrary to alpha-tocopherol, protective effects of L-carnitine and phosphocreatine administrations are due to their regulation of metabolic reactions during hypobaric hypoxia rather than to their scavenger activity.
如大鼠脑中硫代巴比妥酸反应性物质（TBARS）所示，低压缺氧暴露会增加脂质过氧化。血浆乳酸/丙酮酸比值用作缺氧的标志物。我们比较了α-生育酚与L-肉碱或磷酸肌酸的保护作用。预先用α-生育酚、L-肉碱或磷酸肌酸处理的大鼠在低压缺氧暴露后TBARS水平较低。然而，仅在预先用L-肉碱或磷酸肌酸处理的大鼠中乳酸/丙酮酸比值得到改善。我们从数据中得出结论，与α-生育酚相反，L-肉碱和磷酸肌酸给药的保护作用是由于它们在低压缺氧期间对代谢反应的调节，而不是由于它们的清除剂活性。
