Bender Welcome, Fitzgerald Daniel P
Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA.
Development. 2002 Nov;129(21):4923-30. doi: 10.1242/dev.129.21.4923.
A series of mutations have been recovered in the bithorax complex of D. melanogaster that transform the first segment of the abdomen into a copy of the second or third abdominal segment. These dominant Ultraabdominal alleles are all associated with P element insertions which are transcribed in the first abdominal segment. The transcripts proceed past the end of the P element for up to 50 kb, extending through the regulatory regions for the second and third abdominal segments. Blocking transcription from the P element promoter reverts the mutant phenotype. Previously identified Ultraabdominal alleles, not associated with P elements, also show abnormal transcription of the same region.
在黑腹果蝇的双胸复合体中发现了一系列突变，这些突变将腹部的第一节转化为第二节或第三节腹部的副本。这些显性的超腹部等位基因都与P因子插入有关，这些P因子在第一腹节中转录。转录本延伸超过P因子末端达50 kb，穿过第二和第三腹节的调控区域。阻断P因子启动子的转录可使突变表型恢复。先前鉴定的与P因子无关的超腹部等位基因也显示出同一区域的异常转录。
