Karch F, Weiffenbach B, Peifer M, Bender W, Duncan I, Celniker S, Crosby M, Lewis E B
Cell. 1985 Nov;43(1):81-96. doi: 10.1016/0092-8674(85)90014-5.
The homeotic mutations in the right half of the bithorax complex of Drosophila cause segmental transformations in the second through the eighth segments of the fly. A chromosomal walk in the bithorax complex has now been extended 215 kb through the right half of the complex, and lesions for over 40 mutations have been located on the DNA map. The mutations can be grouped in a series of phenotypic classes, one for each abdominal segment, although each mutation typically affects more than one segment. The mutant lesions of each class are clustered, and they are aligned on the chromosome in the order of the body segments that they affect. Complementation tests suggest interactions between widely spaced DNA regions; indeed, the right half cannot be split anywhere without some loss of function.
果蝇双胸复合体右半部分的同源异型突变会导致果蝇第二至第八节段发生节段转化。目前，双胸复合体中的染色体步移已延伸至复合体右半部分215 kb的区域，并且在DNA图谱上定位了40多个突变的损伤位点。这些突变可分为一系列表型类别，每个腹部节段对应一个类别，不过每个突变通常会影响多个节段。每个类别的突变损伤位点聚集在一起，并且它们在染色体上按照所影响的身体节段的顺序排列。互补测验表明，相距较远的DNA区域之间存在相互作用；实际上，右半部分在任何位置进行分割都会导致某种功能丧失。
