Minelli R, Reggiani C, Dionigi R, Cappelli V
Pflugers Arch. 1975 Aug 29;359(1-2):69-80. doi: 10.1007/BF00581278.
The choice of a suitable muscle model consistent with the mechanical behaviour of Rat papillary muscle at rest or during isotonic or isometric contraction has been considered. Three different preload levels within the ascending limb of the Frank-Starling curve have been used in five papillary muscles. Series elastic (SE) and parallel elastic (PE) length-tension relationships have been evaluated according to five mechanical muscle models using data from systolic and diastolic quick-release manoeuvres. For each preload level and muscle model, the time course of the force-velocity relationship of the contractile element (CE) has been calculated using a PDP 8/L digital computer. Several mechanical and biological characteristics are considered which exclude four of the five selected muscle models. The Maxwell model with a damper seems to be the most suitable mechanical model for Rat papillary muscle. According to the selected muscle model it seems that VCEmax is dependent on muscle length variation; the reliability of this parameter as an index of myocardial contractility is discussed.
已经考虑选择一种与大鼠乳头肌在静息状态或等张或等长收缩期间的力学行为相一致的合适肌肉模型。在五条乳头肌中使用了Frank-Starling曲线上升支内的三种不同预负荷水平。根据五种机械肌肉模型，利用收缩期和舒张期快速释放操作的数据，评估了串联弹性（SE）和平行弹性（PE）长度-张力关系。对于每种预负荷水平和肌肉模型，使用PDP 8/L数字计算机计算了收缩元件（CE）的力-速度关系的时间进程。考虑了几个机械和生物学特征，这排除了五个选定肌肉模型中的四个。带有阻尼器的麦克斯韦模型似乎是大鼠乳头肌最合适的力学模型。根据选定的肌肉模型，VCE max似乎取决于肌肉长度变化；讨论了该参数作为心肌收缩性指标的可靠性。
