Németh János, Knézy Krisztina, Tapasztó Beáta, Kovács Rita, Harkányi Zoltán
First Department of Ophthalmology, Semmelweis University, Tömo u. 25-29, 1083 Budapest, Hungary.
Graefes Arch Clin Exp Ophthalmol. 2002 Oct;240(10):835-40. doi: 10.1007/s00417-002-0552-1. Epub 2002 Sep 26.
Prospective examination of the influence of changes in heart rate, arterial blood pressure and intraocular pressure induced by short dynamic exercise on orbital blood-flow velocities, and comparison of the autoregulation response in the ophthalmic artery and the central retinal artery.
Twelve young healthy volunteers were involved in the ophthalmic artery study and 12 others in the central retinal artery study. Blood-flow velocities were measured using color Doppler imaging before and after exercise.
After exercise systolic blood pressure and heart rate were higher ( P<0.004) and intraocular pressure was lower ( P<0.006). However, in the central retinal artery the mean flow velocity, end-diastolic velocity and resistive indices remained stable, while in the ophthalmic artery these velocities actually decreased, and resistive indices increased significantly ( P<0.005). In the central retinal vein the velocities showed no significant change.
Our results confirm the presence of an effective compensatory autoregulation for the retinal circulation, in connection with an increase in the ocular perfusion pressure induced by exercise. However, we found that in the ophthalmic artery some over-compensation occurs (significant decrease in some velocity parameters), whereas in the central retinal artery important flow parameters (mean velocity, end-diastolic velocity and resistive indices) appear to be successfully stabilized. Exercise history, heart rate, blood pressure and intraocular pressure all have to be monitored in orbital blood flow studies, as these variables are strongly affected by the changes in the autonomic nervous system and in turn significantly influence the measured flow velocity and resistivity values.
前瞻性研究短时间动态运动引起的心率、动脉血压和眼压变化对眼眶血流速度的影响，并比较眼动脉和视网膜中央动脉的自动调节反应。
12名年轻健康志愿者参与眼动脉研究，另外12名参与视网膜中央动脉研究。运动前后使用彩色多普勒成像测量血流速度。
运动后收缩压和心率升高（P<0.004），眼压降低（P<0.006）。然而，视网膜中央动脉的平均流速、舒张末期流速和阻力指数保持稳定，而眼动脉的这些流速实际上下降，阻力指数显著增加（P<0.005）。视网膜中央静脉的流速无显著变化。
我们的结果证实，随着运动引起的眼灌注压升高，视网膜循环存在有效的代偿性自动调节。然而，我们发现眼动脉存在一些过度代偿（一些速度参数显著下降），而视网膜中央动脉的重要血流参数（平均流速、舒张末期流速和阻力指数）似乎成功稳定。在眼眶血流研究中，必须监测运动史、心率、血压和眼压，因为这些变量受自主神经系统变化的强烈影响，进而显著影响测量的流速和阻力值。
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