Nelson-Filho Paulo, Leonardo Mario Roberto, Silva Léa Assed Bezerra, Assed Sada
Department of Pediatric Dentistry, School of Dentistry of Ribeirão Preto, University of São Paulo, Brazil.
J Endod. 2002 Oct;28(10):694-6. doi: 10.1097/00004770-200210000-00004.
The aim of this study was the radiographic evaluation of the apical and periapical region of dog teeth submitted to intracanal bacterial endotoxin (lipopolysaccharide, LPS), associated or not with calcium hydroxide. After removal of the pulp, 60 premolars were divided into four groups and were filled with bacterial endotoxin (group 1), bacterial endotoxin plus calcium hydroxide (group 2), saline solution (group 3), or periapical lesions were induced with no treatment (group 4), for a period of 30 days. Similar periapical lesions were observed in groups 1 and 4. The lamina dura was intact in groups 2 and 3. Bacterial endotoxin (LPS) caused radiographically visible periapical lesions, but when associated with calcium hydroxide, this endotoxin was detoxified.
本研究的目的是对犬齿根管内注射细菌内毒素（脂多糖，LPS）、联合或不联合氢氧化钙后的根尖和根尖周区域进行影像学评估。去除牙髓后，将60颗前磨牙分为四组，分别用细菌内毒素填充（第1组）、细菌内毒素加氢氧化钙填充（第2组）、生理盐水填充（第3组），或不进行治疗诱导根尖周病变（第4组），持续30天。第1组和第4组观察到类似的根尖周病变。第2组和第3组的硬骨板完整。细菌内毒素（LPS）导致影像学可见的根尖周病变，但与氢氧化钙联合时，这种内毒素被解毒。
