Romero Roberto, Espinoza Jimmy, Chaiworapongsa Tinnakorn, Kalache Karim
Perinatology Research Branch, NICHD/NIH, Bethesda, MD, USA.
Semin Neonatol. 2002 Aug;7(4):259-74. doi: 10.1016/s1084-2756(02)90121-1.
This article reviews the role of infection in spontaneous premature parturition, the pathways of ascending intrauterine infection, microbiology, and the frequency of intra-amniotic infection in obstetrical complications leading to premature delivery. The evidence that infection is causally linked to premature birth is critically examined, as is the relationship between urogenital tract infection/colonization with microorganisms and the risk of preterm birth. The effect of antibiotic administration in perinatal outcome in patients with preterm labor and intact membranes, preterm premature rupture of membranes, asymptomatic bacteriuria, Group B streptococcus and genital mycoplasmas of the lower genital tract, and bacterial vaginosis are critically examined.
本文综述了感染在自发性早产中的作用、宫内感染上行途径、微生物学以及导致早产的产科并发症中羊膜腔内感染的发生率。对感染与早产存在因果关系的证据进行了严格审查，同时也审查了泌尿生殖道感染/微生物定植与早产风险之间的关系。还对使用抗生素对胎膜完整的早产患者、胎膜早破早产患者、无症状菌尿患者、B族链球菌及下生殖道生殖支原体感染患者以及细菌性阴道病患者围产期结局的影响进行了严格审查。
