Ackerman Z, Karmeli F, Rachmilewitz D
Department of Medicine, Hadassah University Hospital, Mount Scopus, Hebrew University-Hadassah Medical School, Jerusalem, Israel.
Prostaglandins Leukot Essent Fatty Acids. 2002 Oct;67(4):197-201. doi: 10.1054/plef.2002.0419.
It has been suggested that the arteriolar vasodilatation and hyperdynamic circulation observed in rats with partial portal vein ligation (PPVL) is caused by increased splanchnic and systemic delivery of vasodilator substances. The aims of our study were to determine organ-specific generation of prostaglandin E(2) (PGE(2)) in rats with PPVL during the evolution of portal hypertension. Rats with PPVL and sham-operated (S) rats were studied in the first, third, fourth and 14th postoperative days. They were anesthetized and splenic pulp pressure and blood pressure were measured. Spleen, colon and lungs were removed and the splenic, pulmonary and mucosal colonic PGE(2) were determined. All PPVL rats developed sequential hemodynamic changes compatible with evolving portal hypertension. Splenic pulp pressure was higher in PPVL rats compared with S rats during all days of the study. Within the group of PPVL the splenic pulp pressure was higher in the first postoperative day and decreased in the ensuing days. No changes in splenic and colonic PGE(2) generation were noted during the study period. Pulmonary PGE(2) generation increased significantly in the first postoperative day in PPVL rats compared with S rats. However, similar increase was observed on the third postoperative day in S rats. PGE(2) probably has no role in splanchnic hemodynamic changes during evolution of portal hypertension. Pulmonary PGE(2) generation may increase as a response to increased portal pressure, or to abdominal surgery.
有人提出，在部分门静脉结扎（PPVL）的大鼠中观察到的小动脉血管舒张和高动力循环是由内脏和全身血管扩张物质输送增加所致。我们研究的目的是确定门静脉高压发展过程中PPVL大鼠体内前列腺素E2（PGE2）的器官特异性生成情况。在术后第1天、第3天、第4天和第14天对PPVL大鼠和假手术（S）大鼠进行研究。将它们麻醉后测量脾髓压和血压。取出脾脏、结肠和肺脏，测定脾脏、肺脏和结肠黏膜的PGE2。所有PPVL大鼠均出现与门静脉高压发展相符的一系列血流动力学变化。在研究的所有天数中，PPVL大鼠的脾髓压均高于S大鼠。在PPVL组中，术后第1天脾髓压较高，随后几天有所下降。在研究期间，未观察到脾脏和结肠PGE2生成的变化。与S大鼠相比，PPVL大鼠术后第1天肺脏PGE2生成显著增加。然而，在S大鼠术后第3天也观察到了类似的增加。在门静脉高压发展过程中，PGE2可能在内脏血流动力学变化中不起作用。肺脏PGE2生成可能是对门静脉压力升高或腹部手术的一种反应而增加。
