Menten Patricia, Wuyts Anja, Van Damme Jo
Laboratory of Molecular Immunology, Rega Institute for Medical Research, Minderbroedersstraat 10, B-3000, Leuven Belgium.
Cytokine Growth Factor Rev. 2002 Dec;13(6):455-81. doi: 10.1016/s1359-6101(02)00045-x.
Macrophage inflammatory protein-1alpha (MIP-1alpha) and MIP-1beta are highly related members of the CC chemokine subfamily. Despite their structural similarities, MIP-1alpha and MIP-1beta show diverging signaling capacities. Depending on the MIP-1 subtype and its NH(2)-terminal processing, one or more of the CC chemokine receptors CCR1, CCR2, CCR3 and CCR5 are recognized. Since both human MIP-1alpha subtypes (LD78alpha and LD78beta) and MIP-1beta signal through CCR5, the major co-receptor for M-tropic HIV-1 strains, these chemokines are capable of inhibiting HIV-1 infection in susceptible cells. In this review, different aspects of human and mouse MIP-1alpha and MIP-1beta are discussed, including their protein and gene structures, their regulated production, their receptor usage and biological activities and their role in several pathologies including HIV-1 infection.
巨噬细胞炎性蛋白-1α（MIP-1α）和MIP-1β是CC趋化因子亚家族中高度相关的成员。尽管它们在结构上相似，但MIP-1α和MIP-1β显示出不同的信号传导能力。根据MIP-1亚型及其氨基末端加工情况，CC趋化因子受体CCR1、CCR2、CCR3和CCR5中的一个或多个会被识别。由于人类的两种MIP-1α亚型（LD78α和LD78β）以及MIP-1β都通过CCR5信号传导，而CCR5是M型嗜亲性HIV-1毒株的主要共受体，因此这些趋化因子能够抑制HIV-1在易感细胞中的感染。在这篇综述中，将讨论人类和小鼠MIP-1α及MIP-1β的不同方面，包括它们的蛋白质和基因结构、它们的调节性产生、它们的受体使用情况和生物学活性以及它们在包括HIV-1感染在内的几种病理状况中的作用。
