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CD131通过促进巨噬细胞浸润参与溃疡性结肠炎的发病机制。

CD131 contributes to ulcerative colitis pathogenesis by promoting macrophage infiltration.

作者信息

Wu Zhiyuan, Liu Lindi, He Chenchen, Xiao Lin, Yun Duo, Chen Junliang, Liu Zhihao, Li Wenjun, Lv Qingjie, Tan Xiaodong

机构信息

Department of General Surgery, Shengjing Hospital of China Medical University, Shenyang, China.

Department of Pathology, Shengjing Hospital of China Medical University, Shenyang, China.

出版信息

Elife. 2025 Jun 30;13:RP102637. doi: 10.7554/eLife.102637.

DOI:10.7554/eLife.102637
PMID:40586774
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12208661/
Abstract

BACKGROUND

Ulcerative colitis (UC) is a group of chronic inflammatory bowel disease mainly affecting the colon. The exact etiology of UC remains elusive. CD131 is a receptor subunit mediating the effects of hematopoietic growth factors granulocyte-macrophage colony-stimulating factor (GM-CSF) and Interleukin-3 (IL-3), which regulate various inflammatory responses. The pleiotropic effects of the cytokines on intestinal inflammation suggest that additional factors influence their overall function, where the receptor may play a role.

METHODS

In the present study, we investigated the role of CD131 in the pathogenesis of UC, with the use of murine colitis model established by administration of dextran sulfate sodium (DSS) in the drinking water.

RESULTS

By comparing the immune and inflammatory responses between wt and CD131-deficient mice, we found that CD131 contributed to DSS-induced murine colitis, which functioned in synergy with tissue-infiltrating macrophages. Besides, CD131 may have promoted the chemotaxis of macrophages and T cells into the colon through CCL4. In addition, we analyzed clinical data and pathology specimens from UC patients and found that CD131 was associated with the endoscopic and pathological severity of intestinal inflammation.

CONCLUSIONS

The present study provides a novel way to the understanding of the mechanisms of GM-CSF and IL-3 effects in the intestine, which will benefit the development of therapeutic approaches.

FUNDING

The present work has received no external funding but only from the affiliated institution.

摘要

背景

溃疡性结肠炎（UC）是一组主要影响结肠的慢性炎症性肠病。UC的确切病因仍不清楚。CD131是一种受体亚基，介导造血生长因子粒细胞-巨噬细胞集落刺激因子（GM-CSF）和白细胞介素-3（IL-3）的作用，这些因子调节各种炎症反应。细胞因子对肠道炎症的多效性作用表明，其他因素会影响它们的整体功能，而受体可能在其中发挥作用。

方法

在本研究中，我们利用通过在饮用水中给予葡聚糖硫酸钠（DSS）建立的小鼠结肠炎模型，研究了CD131在UC发病机制中的作用。

结果

通过比较野生型和CD131缺陷型小鼠之间的免疫和炎症反应，我们发现CD131促成了DSS诱导的小鼠结肠炎，它与组织浸润巨噬细胞协同发挥作用。此外，CD131可能通过CCL4促进巨噬细胞和T细胞向结肠的趋化作用。此外，我们分析了UC患者的临床数据和病理标本，发现CD131与肠道炎症的内镜和病理严重程度相关。

结论

本研究为理解GM-CSF和IL-3在肠道中的作用机制提供了一种新方法，这将有利于治疗方法的开发。

资助

本研究未获得外部资助，仅得到附属机构的支持。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/78ec/12208661/419b94cf420a/elife-102637-fig5.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/78ec/12208661/419b94cf420a/elife-102637-fig5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/78ec/12208661/5526e60bd383/elife-102637-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/78ec/12208661/3f08c36ed7f6/elife-102637-fig1-figsupp1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/78ec/12208661/4914159a782d/elife-102637-fig1-figsupp2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/78ec/12208661/d606cbf68243/elife-102637-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/78ec/12208661/e1b6b23ade37/elife-102637-fig2-figsupp1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/78ec/12208661/b00dbf5f305f/elife-102637-fig2-figsupp2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/78ec/12208661/da54aaeb3bde/elife-102637-fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/78ec/12208661/d9ad6626d395/elife-102637-fig3-figsupp1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/78ec/12208661/49f587a8ca16/elife-102637-fig3-figsupp2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/78ec/12208661/8c875aa64bc9/elife-102637-fig4.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/78ec/12208661/419b94cf420a/elife-102637-fig5.jpg

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Cell Rep. 2023 Jun 27;42(6):112637. doi: 10.1016/j.celrep.2023.112637. Epub 2023 Jun 8.
2
CSF2-dependent monocyte education in the pathogenesis of ANCA-induced glomerulonephritis.CSF2 依赖性单核细胞在抗中性粒细胞胞浆抗体诱导性肾小球肾炎发病机制中的作用。
Ann Rheum Dis. 2022 Aug;81(8):1162-1172. doi: 10.1136/annrheumdis-2021-221984. Epub 2022 Apr 13.
3
Macrophage immunometabolism in inflammatory bowel diseases: From pathogenesis to therapy.
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Pharmacol Ther. 2022 Oct;238:108176. doi: 10.1016/j.pharmthera.2022.108176. Epub 2022 Mar 26.
4
Regulation and Role of αE Integrin and Gut Homing Integrins in Migration and Retention of Intestinal Lymphocytes during Inflammatory Bowel Disease.αE 整合素和肠道归巢整合素在炎症性肠病期间对肠道淋巴细胞迁移和滞留的调控和作用。
J Immunol. 2021 Nov 1;207(9):2245-2254. doi: 10.4049/jimmunol.2100220. Epub 2021 Sep 24.
5
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Innovation (Camb). 2021 Jul 1;2(3):100141. doi: 10.1016/j.xinn.2021.100141. eCollection 2021 Aug 28.
6
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Cell Mol Gastroenterol Hepatol. 2021;12(1):321-333. doi: 10.1016/j.jcmgh.2021.03.002. Epub 2021 Mar 6.
7
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N Engl J Med. 2020 Dec 31;383(27):2652-2664. doi: 10.1056/NEJMra2002697.
8
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Cell Rep. 2020 Jul 7;32(1):107857. doi: 10.1016/j.celrep.2020.107857.
9
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10
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Nat Rev Gastroenterol Hepatol. 2019 Sep;16(9):531-543. doi: 10.1038/s41575-019-0172-4. Epub 2019 Jul 16.