小干扰RNA。RNA沉默指南。

siRNA. A guide for RNA silencing.

作者信息

Ramaswamy Gopalakrishna, Slack Frank J

机构信息

Department of Molecular, Cellular and Developmental Biology, Yale University, 266 Whitney Avenue, New Haven, CT 06520, USA.

出版信息

Chem Biol. 2002 Oct;9(10):1053-5. doi: 10.1016/s1074-5521(02)00249-1.

DOI:10.1016/s1074-5521(02)00249-1

PMID:12401489

Abstract

RNAi is routinely used to eliminate gene activity for experimental purposes. However, the precise molecular mechanism of RNAi is unknown. Recent papers partially illuminate this mechanism in human cells, advancing the potential application of RNAi toward the treatment of human disease.

摘要

RNA干扰通常用于为实验目的消除基因活性。然而，RNA干扰的确切分子机制尚不清楚。最近的论文部分阐明了这种机制在人类细胞中的情况，推动了RNA干扰在人类疾病治疗方面的潜在应用。