Kitagishi Yasuko, Okumura Naoko, Yoshida Hitomi, Tateishi Chika, Nishimura Yuri, Matsuda Satoru
Department of Environmental Health Science, Nara Women's University, Kita-Uoya Nishimachi, Nara 630-8506, Japan.
J Amino Acids. 2011;2011:782187. doi: 10.4061/2011/782187. Epub 2011 Jun 9.
Dicer is an RNase III enzyme with two catalytic subunits, which catalyzes the cleavage of double-stranded RNA to small interfering RNAs and micro-RNAs, which are mainly involved in invasive nucleic acid defense and endogenous genes regulation. Dicer is abundantly expressed in embryos, indicating the importance of the protein in early embryonic development. In addition, Dicer is thought to be involved in defense mechanism against foreign nucleic acids such as viruses. This paper will mainly focus on the recent progress of Dicer-related research and discuss potential RNA interference pathways in aquatic species.
Dicer是一种具有两个催化亚基的核糖核酸酶III，它催化双链RNA切割成小干扰RNA和微小RNA，这些小RNA主要参与侵入性核酸防御和内源基因调控。Dicer在胚胎中大量表达，表明该蛋白在早期胚胎发育中具有重要作用。此外，Dicer被认为参与针对病毒等外来核酸的防御机制。本文将主要聚焦于Dicer相关研究的最新进展，并探讨水生物种中潜在的RNA干扰途径。
