Wijetunga Mevan, Rockson Stanley
Department of Medicine, University of Hawaii, Honolulu, Hawaii, USA.
Am J Med. 2002 Oct 1;113(5):419-23. doi: 10.1016/s0002-9343(02)01223-8.
Although clinical manifestations of myocarditis in systemic lupus erythematosus are uncommon, noninvasive cardiac testing may detect subclinical cases. The pathogenesis of myocarditis in systemic lupus erythematosus has been ascribed to many factors, including autoimmunity, medications, and coexisting diseases. Lupus myocarditis merits urgent clinical attention because of the likely progression to arrhythmias, conduction disturbances and heart block, dilated cardiomyopathy, and heart failure. Endomyocardial biopsy can be used to identify the underlying inflammatory histopathology. Usual therapy includes high-dose corticosteroids, in addition to standard cardiac medications.
尽管系统性红斑狼疮中心肌炎的临床表现并不常见，但非侵入性心脏检查可能会发现亚临床病例。系统性红斑狼疮中心肌炎的发病机制归因于多种因素，包括自身免疫、药物和并存疾病。狼疮性心肌炎因可能进展为心律失常、传导障碍和心脏传导阻滞、扩张型心肌病及心力衰竭而值得临床紧急关注。心内膜活检可用于识别潜在的炎症组织病理学。常规治疗除标准心脏药物外，还包括大剂量皮质类固醇。
